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Long-term outcomes in mouse models of ischemia-reperfusion-induced acute kidney injury.
Scarfe, Lauren; Menshikh, Anna; Newton, Emily; Zhu, Yuantee; Delgado, Rachel; Finney, Charlene; de Caestecker, Mark P.
Afiliación
  • Scarfe L; Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
  • Menshikh A; Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
  • Newton E; Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
  • Zhu Y; Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
  • Delgado R; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee.
  • Finney C; Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
  • de Caestecker MP; Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Am J Physiol Renal Physiol ; 317(4): F1068-F1080, 2019 10 01.
Article en En | MEDLINE | ID: mdl-31411074
Severe acute kidney injury has a high mortality and is a risk factor for progressive chronic kidney disease. None of the potential therapies that have been identified in preclinical studies have successfully improved clinical outcomes. This failure is partly because animal models rarely reflect the complexity of human disease: most preclinical studies are short term and are commonly performed in healthy, young, male mice. Therapies that are effective in preclinical models that share common clinical features seen in patients with acute kidney injury, including genetic diversity, different sexes, and comorbidities, and evaluate long-term outcomes are more likely to predict success in the clinic. Here, we evaluated susceptibility to chronic kidney disease after ischemia-reperfusion injury with delayed nephrectomy by monitoring long-term functional and histological responses to injury. We defined conditions required to induce long-term postinjury renal dysfunction and fibrosis without increased mortality in a reproducible way and evaluate effect of mouse strains, sexes, and preexisting diabetes on these responses.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Daño por Reperfusión / Lesión Renal Aguda Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Am J Physiol Renal Physiol Asunto de la revista: FISIOLOGIA / NEFROLOGIA Año: 2019 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Daño por Reperfusión / Lesión Renal Aguda Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Am J Physiol Renal Physiol Asunto de la revista: FISIOLOGIA / NEFROLOGIA Año: 2019 Tipo del documento: Article