Efficacy and Safety of the Local Application of Mitomycin C to Recurrent Esophageal Strictures in Children.
J Pediatr Gastroenterol Nutr
; 69(5): 528-532, 2019 11.
Article
en En
| MEDLINE
| ID: mdl-31436711
ABSTRACT
OBJECTIVES:
Research on long-term use of mitomycin C (MC) for recurrent esophageal stenoses is limited. We assessed the long-term efficacy and safety of local application of MC for recurrent esophageal stenoses in children.METHODS:
This was a retrospective study of 39 patients (17 girls) with a median age of 19.5 months (range 2.4-196.0) at the time of MC application. The etiologies of stenosis were esophageal atresia (nâ=â25), caustic ingestion (nâ=â9), congenital esophageal stenosis (nâ=â3), and other causes (nâ=â2). Stenosis was single in 35 (90%) patients and multiple in 4 (10%). Before MC, patients underwent multiple repeated dilations (median 3 dilations per child [range 2-26]) over a median period of 7 months (range 2.6-49.3). Treatment success was defined a priori as a reduction in the number of dilations over the same period from before to after the application of MC.RESULTS:
For 26 (67%) patients, the application of MC was considered a success 102 versus 17 dilatations (Pâ<â0.0001). Sixteen (41%) patients never required additional dilation during the follow-up after MC application (median 3.1 years [range 0.6-8.5]). No complication related to MC was observed. Biopsies at the site of MC application were performed at maximal follow-up in 16 patients and revealed no dysplasia. Three factors were associated with success of MC single stenosis, short stenosis, and esophageal atresia type III.CONCLUSIONS:
This study is the largest series reported showing that topical application of MC is an efficient and safe treatment for recurrent esophageal stenosis in children.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Mitomicina
/
Estenosis Esofágica
/
Antibióticos Antineoplásicos
Tipo de estudio:
Observational_studies
Límite:
Adolescent
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Child
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Child, preschool
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Female
/
Humans
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Infant
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Male
Idioma:
En
Revista:
J Pediatr Gastroenterol Nutr
Año:
2019
Tipo del documento:
Article