Opioid-Induced Foregut Dysfunction.
Am J Gastroenterol
; 114(11): 1716-1725, 2019 11.
Article
en En
| MEDLINE
| ID: mdl-31464739
ABSTRACT
The impact of opioid use on the lower gastrointestinal tract is well described, but recent opioid crisis has caused increased awareness of the detrimental effects of these drugs on esophageal and gastroduodenal motility. Opioid use has been associated with increased incidence of spastic esophageal motility disorders and gastroduodenal dysfunction. Opioid receptors are present with high abundance in the myenteric and submucosal plexus of the enteric nervous system. Activation of these receptors leads to suppressed excitability of the inhibitory musculomotor neurons and unchecked tonic contraction of the autogenic musculature (such as the lower esophageal sphincter and the pylorus).
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Sistema Nervioso Entérico
/
Enfermedades Gastrointestinales
/
Analgésicos Opioides
/
Trastornos Relacionados con Opioides
Límite:
Humans
Idioma:
En
Revista:
Am J Gastroenterol
Año:
2019
Tipo del documento:
Article
País de afiliación:
Estados Unidos