Contamination of hybrid hernia meshes compared to bioresorbable Phasix™ Mesh in a rabbit subcutaneous implant inoculation model.
Ann Med Surg (Lond)
; 46: 12-16, 2019 Oct.
Article
en En
| MEDLINE
| ID: mdl-31467674
ABSTRACT
BACKGROUND:
Hybrid hernia meshes combine biological tissue-derived extracellular matrix with permanent or resorbable synthetic. The objective of this study was to evaluate hybrid meshes (Gore® Synecor, Zenapro™, Ovitex™ 1S Reinforced Bioscaffold Permanent, and Ovitex™ 1S Reinforced Bioscaffold Resorbable) compared to non-hybrid, bioresorbable synthetic mesh (Phasix™ Mesh) in a rabbit bacterial inoculation model. MATERIALS ANDMETHODS:
Subcutaneous pockets were bilaterally created in male, New Zealand White rabbits (nâ¯=â¯25). Circular meshes (3.8â¯cm diameter) were implanted and inoculated with 1â¯×â¯106 colony forming units (CFU) of clinically-isolated methicillin-resistant Staphylococcus aureus (MRSA). A given animal received a single mesh type. Seven days post-inoculation, animals were euthanized and white material and microbial colonization were assessed by abscess scoring and CFU quantification, respectively. Non-parametric Kruskal-Wallis with Dunn's post-hoc tests compared results for different meshes.RESULTS:
Phasix™ Mesh and Synecor exhibited significantly lower abscess scores than Zenapro™, Ovitex™ 1S Permanent, and Ovitex™ 1S Resorbable (pâ¯<â¯0.05). All pocket swabs for Zenapro™ and Ovitex™ meshes were positive for MRSA (100%), with 20% of Synecor and 0% Phasix™ Mesh. Microbial colonization was significantly lower for Phasix™ Mesh (0â¯CFU) relative to Zenapro™ (6.73â¯×â¯107â¯CFU (median)), Ovitex™ 1S Permanent (7.87â¯×â¯107â¯CFU) and Ovitex™ 1S Resorbable (1.45â¯×â¯108â¯CFU), and for Synecor (0â¯CFU) relative to both Ovitex™ meshes. Phasix™ Mesh was the only device with no detectable abscess or microbial colonization.CONCLUSION:
Phasix™ Mesh demonstrated no detectable abscess or microbial colonization at 7-days post-implantation and inoculation, in contrast with four hybrid meshes, which all demonstrated colonization in a rabbit bacterial inoculation model.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Ann Med Surg (Lond)
Año:
2019
Tipo del documento:
Article
País de afiliación:
Estados Unidos