Liver Stiffness Assessed by Ultrasound Shear Wave Elastography from General Electric Accurately Predicts Clinically Significant Portal Hypertension in Patients with Advanced Chronic Liver Disease.
Ultraschall Med
; 41(5): 526-533, 2020 Oct.
Article
en En
| MEDLINE
| ID: mdl-31476787
ABSTRACT
PURPOSE:
Clinically significant portal hypertension (CSPH) is responsible for most of the complications in patients with cirrhosis. Liver stiffness (LS) measurement by vibration-controlled transient elastography (VCTE) is currently used to evaluate CSPH. Bi-dimensional shear wave elastography from General Electric (2D-SWE.GE) has not yet been validated for the diagnosis of PHT. Our aims were to test whether 2D-SWE.GE-LS is able to evaluate CSPH, to determine the reliability criteria of the method and to compare its accuracy with that of VCTE-LS in this clinical setting. MATERIALS ANDMETHODS:
Patients with chronic liver disease referred to hepatic catheterization (HVPG) were consecutively enrolled. HVPG and LS by both VCTE and 2D-SWE.GE were performed on the same day. The diagnostic performance of each LS method was compared against HVPG and between each other.RESULTS:
2D-SWE.GE-LS was possible in 123/127 (96.90â%) patients. The ability to record at least 5 LS measurements by 2D-SWE.GE and IQRâ<â30â% were the only features associated with reliable results. 2D-SWE.GE-LS was highly correlated with HVPG (râ=â0.704; pâ<â0.0001), especially if HVPG <â10âmmHg and was significantly higher in patients with CSPH (15.52 vs. 8.14âkPa; pâ<â0.0001). For a cut-off value of 11.3âkPa, the AUROC of 2D-SWE.GE-LS to detect CSPH was 0.91, which was not inferior to VCTE-LS (0.92; pâ=â0.79). The diagnostic accuracy of LS by 2D-SWE.GE-LS to detect CSPH was similar with the one of VCTE-LS (83.74â% vs. 85.37â%; pâ=â0.238). The diagnostic accuracy was not enhanced by using different cut-off values which enhanced the sensitivity or the specificity. However, in the subgroup of compensated patients with alcoholic liver disease, 2D-SWE.GE-LS classified CSPH better than VCTE-LS (93.33â% vs. 85.71â%, pâ=â0.039).CONCLUSION:
2D-SWE.GE-LS has good accuracy, not inferior to VCTE-LS, for the diagnosis of CSPH.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Diagnóstico por Imagen de Elasticidad
/
Hipertensión Portal
/
Hígado
/
Cirrosis Hepática
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Ultraschall Med
Año:
2020
Tipo del documento:
Article
País de afiliación:
Rumanía