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Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens.
Clausse, Victor; Tao, Dingyin; Debnath, Subrata; Fang, Yuhong; Tagad, Harichandra D; Wang, Yuhong; Sun, Hongmao; LeClair, Christopher A; Mazur, Sharlyn J; Lane, Kelly; Shi, Zhen-Dan; Vasalatiy, Olga; Eells, Rebecca; Baker, Lynn K; Henderson, Mark J; Webb, Martin R; Shen, Min; Hall, Matthew D; Appella, Ettore; Appella, Daniel H; Coussens, Nathan P.
Afiliación
  • Clausse V; Synthetic Bioactive Molecules Section, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, Maryland 20892.
  • Tao D; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850.
  • Debnath S; Laboratory of Cell Biology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892.
  • Fang Y; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850.
  • Tagad HD; Laboratory of Cell Biology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892.
  • Wang Y; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850.
  • Sun H; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850.
  • LeClair CA; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850.
  • Mazur SJ; Laboratory of Cell Biology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892.
  • Lane K; Imaging Probe Development Center, NHLBI, National Institutes of Health, Rockville, Maryland 20850.
  • Shi ZD; Imaging Probe Development Center, NHLBI, National Institutes of Health, Rockville, Maryland 20850.
  • Vasalatiy O; Imaging Probe Development Center, NHLBI, National Institutes of Health, Rockville, Maryland 20850.
  • Eells R; Reaction Biology Corporation, 1 Great Valley Parkway, Suite 2, Malvern, Pennsylvania 19355.
  • Baker LK; Reaction Biology Corporation, 1 Great Valley Parkway, Suite 2, Malvern, Pennsylvania 19355.
  • Henderson MJ; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850.
  • Webb MR; Francis Crick Institute, 1 Midland Road, London NW1 AT, United Kingdom.
  • Shen M; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850.
  • Hall MD; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 hallma@mail.nih.gov.
  • Appella E; Laboratory of Cell Biology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892.
  • Appella DH; Synthetic Bioactive Molecules Section, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, Maryland 20892.
  • Coussens NP; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 coussensn@mail.nih.gov.
J Biol Chem ; 294(46): 17654-17668, 2019 11 15.
Article en En | MEDLINE | ID: mdl-31481464

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fosfopéptidos / Activadores de Enzimas / Bibliotecas de Moléculas Pequeñas / Proteína Fosfatasa 2C Límite: Humans Idioma: En Revista: J Biol Chem Año: 2019 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fosfopéptidos / Activadores de Enzimas / Bibliotecas de Moléculas Pequeñas / Proteína Fosfatasa 2C Límite: Humans Idioma: En Revista: J Biol Chem Año: 2019 Tipo del documento: Article