[Clinicopathological features and prognosis of 488 patients with neuroendocrine tumors].
Zhonghua Yi Xue Za Zhi
; 99(32): 2527-2531, 2019 Aug 27.
Article
en Zh
| MEDLINE
| ID: mdl-31484281
ABSTRACT
Objective:
To investigate the clinicopathological features and prognosis of patients with neuroendocrine tumors (NETs).Methods:
The clinicopathologic data of enrolled patients with NETs between October 2012 and October 2017 at the First Affiliated Hospital of Zhengzhou University were retrospectively analyzed.Results:
Among the 488 NETs patients, the average age was (51.0±15.8) years, and the sex ratio (male/female) was 1â¶1.1. Of the NETs, 370 were located in the digestive system (75.8%), 63 were pulmonary (12.9%), 14 were mediastinal (2.9%), 7 were of unknown primary origin (1.4%), and 34 were located in other sites (7.0%). Among the NETs, the pancreas, rectum and stomach were the most common sites. In the digestive system NETs, the most common tumor grade was G1 (190 cases, 51.4%), followed by G2 (143 cases, 38.6%) and NET-G3 (37 cases, 10.0%). In pulmonary NETs, typical and atypical carcinoid tumors was 47.6% and 52.4%, respectively. There were 310 patients at stage â /â ¡, 53 at stage â ¢, 69 at stage â £ and 56 at stage undiagnosed, respectively. The relationships among age, stage, grade, metastasis, treatment and prognosis were analyzed. All these factors could influence the survival rate of NET patients. Multivariate Cox analysis showed that age (>50 years old) (HR=2.831, 95%CI1.414-7.029, P=0.025) and distant metastasis (HR=10.208, 95%CI4.110-25.355, P<0.001) were independent risk factors.Conclusions:
The most common primary sites of NETs are the pancreas, rectum, and stomach. Age and distant metastasis are independent risk factors for the prognosis of NETs.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Pancreáticas
/
Tumores Neuroendocrinos
/
Neoplasias Intestinales
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
/
Female
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Humans
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Male
/
Middle aged
Idioma:
Zh
Revista:
Zhonghua Yi Xue Za Zhi
Año:
2019
Tipo del documento:
Article
País de afiliación:
China