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Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease.
Hickson, LaTonya J; Langhi Prata, Larissa G P; Bobart, Shane A; Evans, Tamara K; Giorgadze, Nino; Hashmi, Shahrukh K; Herrmann, Sandra M; Jensen, Michael D; Jia, Qingyi; Jordan, Kyra L; Kellogg, Todd A; Khosla, Sundeep; Koerber, Daniel M; Lagnado, Anthony B; Lawson, Donna K; LeBrasseur, Nathan K; Lerman, Lilach O; McDonald, Kathleen M; McKenzie, Travis J; Passos, João F; Pignolo, Robert J; Pirtskhalava, Tamar; Saadiq, Ishran M; Schaefer, Kalli K; Textor, Stephen C; Victorelli, Stella G; Volkman, Tammie L; Xue, Ailing; Wentworth, Mark A; Wissler Gerdes, Erin O; Zhu, Yi; Tchkonia, Tamara; Kirkland, James L.
Afiliación
  • Hickson LJ; Cellular Senescence and Translation and Pharmacology Programs, Robert and Arlene Kogod Center on Aging, Mayo Clinic, United States of America; Division of Geriatric Medicine and Gerontology, Department of Medicine, Mayo Clinic, United States of America; Division of Nephrology and Hypertension, Depar
  • Langhi Prata LGP; Cellular Senescence and Translation and Pharmacology Programs, Robert and Arlene Kogod Center on Aging, Mayo Clinic, United States of America.
  • Bobart SA; Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, United States of America.
  • Evans TK; Cellular Senescence and Translation and Pharmacology Programs, Robert and Arlene Kogod Center on Aging, Mayo Clinic, United States of America; Department of Medicine Clinical Trials Unit, Department of Medicine, Mayo Clinic, United States of America.
  • Giorgadze N; Cellular Senescence and Translation and Pharmacology Programs, Robert and Arlene Kogod Center on Aging, Mayo Clinic, United States of America.
  • Hashmi SK; Cellular Senescence and Translation and Pharmacology Programs, Robert and Arlene Kogod Center on Aging, Mayo Clinic, United States of America; Division of Hematology, Department of Medicine, Mayo Clinic, United States of America.
  • Herrmann SM; Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, United States of America.
  • Jensen MD; Division of Endocrinology, Department of Medicine, Mayo Clinic, United States of America.
  • Jia Q; Division of Endocrinology, Department of Medicine, Mayo Clinic, United States of America.
  • Jordan KL; Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, United States of America.
  • Kellogg TA; Department of Surgery, Mayo Clinic, United States of America.
  • Khosla S; Cellular Senescence and Translation and Pharmacology Programs, Robert and Arlene Kogod Center on Aging, Mayo Clinic, United States of America; Division of Endocrinology, Department of Medicine, Mayo Clinic, United States of America.
  • Koerber DM; Cellular Senescence and Translation and Pharmacology Programs, Robert and Arlene Kogod Center on Aging, Mayo Clinic, United States of America.
  • Lagnado AB; Cellular Senescence and Translation and Pharmacology Programs, Robert and Arlene Kogod Center on Aging, Mayo Clinic, United States of America; Department of Physiology and Biomedical Engineering, Mayo Clinic, United States of America.
  • Lawson DK; Division of Hospital Medicine, Department of Medicine, Mayo Clinic, United States of America.
  • LeBrasseur NK; Cellular Senescence and Translation and Pharmacology Programs, Robert and Arlene Kogod Center on Aging, Mayo Clinic, United States of America; Department of Physiology, Mayo Clinic, United States of America; Department of Physical Medicine and Rehabilitation, Mayo Clinic, United States of America.
  • Lerman LO; Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, United States of America.
  • McDonald KM; Cellular Senescence and Translation and Pharmacology Programs, Robert and Arlene Kogod Center on Aging, Mayo Clinic, United States of America; Office of Research Regulatory Support, Mayo Clinic, United States of America.
  • McKenzie TJ; Department of Surgery, Mayo Clinic, United States of America.
  • Passos JF; Cellular Senescence and Translation and Pharmacology Programs, Robert and Arlene Kogod Center on Aging, Mayo Clinic, United States of America; Department of Physiology and Biomedical Engineering, Mayo Clinic, United States of America.
  • Pignolo RJ; Cellular Senescence and Translation and Pharmacology Programs, Robert and Arlene Kogod Center on Aging, Mayo Clinic, United States of America; Division of Geriatric Medicine and Gerontology, Department of Medicine, Mayo Clinic, United States of America; Division of Endocrinology, Department of Medic
  • Pirtskhalava T; Cellular Senescence and Translation and Pharmacology Programs, Robert and Arlene Kogod Center on Aging, Mayo Clinic, United States of America.
  • Saadiq IM; Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, United States of America.
  • Schaefer KK; Cellular Senescence and Translation and Pharmacology Programs, Robert and Arlene Kogod Center on Aging, Mayo Clinic, United States of America.
  • Textor SC; Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, United States of America.
  • Victorelli SG; Cellular Senescence and Translation and Pharmacology Programs, Robert and Arlene Kogod Center on Aging, Mayo Clinic, United States of America; Department of Physiology and Biomedical Engineering, Mayo Clinic, United States of America.
  • Volkman TL; Cellular Senescence and Translation and Pharmacology Programs, Robert and Arlene Kogod Center on Aging, Mayo Clinic, United States of America; Department of Medicine Clinical Trials Unit, Department of Medicine, Mayo Clinic, United States of America.
  • Xue A; Cellular Senescence and Translation and Pharmacology Programs, Robert and Arlene Kogod Center on Aging, Mayo Clinic, United States of America.
  • Wentworth MA; Cellular Senescence and Translation and Pharmacology Programs, Robert and Arlene Kogod Center on Aging, Mayo Clinic, United States of America; Office of Research Regulatory Support, Mayo Clinic, United States of America.
  • Wissler Gerdes EO; Cellular Senescence and Translation and Pharmacology Programs, Robert and Arlene Kogod Center on Aging, Mayo Clinic, United States of America; Department of Medicine Clinical Trials Unit, Department of Medicine, Mayo Clinic, United States of America.
  • Zhu Y; Cellular Senescence and Translation and Pharmacology Programs, Robert and Arlene Kogod Center on Aging, Mayo Clinic, United States of America.
  • Tchkonia T; Cellular Senescence and Translation and Pharmacology Programs, Robert and Arlene Kogod Center on Aging, Mayo Clinic, United States of America. Electronic address: Tchkonia.Tamar@Mayo.edu.
  • Kirkland JL; Cellular Senescence and Translation and Pharmacology Programs, Robert and Arlene Kogod Center on Aging, Mayo Clinic, United States of America; Division of Geriatric Medicine and Gerontology, Department of Medicine, Mayo Clinic, United States of America; Division of Hospital Medicine, Department of M
EBioMedicine ; 47: 446-456, 2019 Sep.
Article en En | MEDLINE | ID: mdl-31542391
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Quercetina / Senescencia Celular / Nefropatías Diabéticas / Dasatinib Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: EBioMedicine Año: 2019 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Quercetina / Senescencia Celular / Nefropatías Diabéticas / Dasatinib Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: EBioMedicine Año: 2019 Tipo del documento: Article