Heterologous Expression of a Cryptic Gene Cluster from Streptomyces leeuwenhoekii C34<sup>T</sup> Yields a Novel Lasso Peptide, Leepeptin.

Gomez-Escribano, Juan Pablo; Castro, Jean Franco; Razmilic, Valeria; Jarmusch, Scott A; Saalbach, Gerhard; Ebel, Rainer; Jaspars, Marcel; Andrews, Barbara; Asenjo, Juan A; Bibb, Mervyn J

Heterologous Expression of a Cryptic Gene Cluster from Streptomyces leeuwenhoekii C34^T Yields a Novel Lasso Peptide, Leepeptin.

Gomez-Escribano, Juan Pablo; Castro, Jean Franco; Razmilic, Valeria; Jarmusch, Scott A; Saalbach, Gerhard; Ebel, Rainer; Jaspars, Marcel; Andrews, Barbara; Asenjo, Juan A; Bibb, Mervyn J.

Afiliación

Gomez-Escribano JP; Department of Molecular Microbiology, John Innes Centre, Norwich, United Kingdom.
Castro JF; Department of Molecular Microbiology, John Innes Centre, Norwich, United Kingdom.
Razmilic V; Centre for Biotechnology and Bioengineering (CeBiB), Department of Chemical Engineering and Biotechnology, Universidad de Chile, Santiago, Chile.
Jarmusch SA; Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Old Aberdeen, United Kingdom.
Saalbach G; Department of Molecular Microbiology, John Innes Centre, Norwich, United Kingdom.
Ebel R; Centre for Biotechnology and Bioengineering (CeBiB), Department of Chemical Engineering and Biotechnology, Universidad de Chile, Santiago, Chile.
Jaspars M; Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Old Aberdeen, United Kingdom.
Andrews B; Department of Molecular Microbiology, John Innes Centre, Norwich, United Kingdom.
Asenjo JA; Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Old Aberdeen, United Kingdom.
Bibb MJ; Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Old Aberdeen, United Kingdom.

Appl Environ Microbiol ; 85(23)2019 12 01.

Article en En | MEDLINE | ID: mdl-31562169

Asunto(s)

Proteínas Bacterianas/genética; Expresión Génica; Familia de Multigenes; Péptidos/genética; Streptomyces/genética; Proteínas Bacterianas/metabolismo; Péptidos/metabolismo; Streptomyces/metabolismo

Palabras clave

RiPP; Streptomyces; heterologous expression; lasso peptide; natural products

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Péptidos / Streptomyces / Proteínas Bacterianas / Expresión Génica / Familia de Multigenes Idioma: En Revista: Appl Environ Microbiol Año: 2019 Tipo del documento: Article País de afiliación: Reino Unido

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