Dopamine delays articular cartilage degradation in osteoarthritis by negative regulation of the NF-&#954;B and JAK2/STAT3 signaling pathways.

Lu, Wei; Ding, Zhenfei; Liu, Fuen; Shan, Wenshan; Cheng, Chao; Xu, Jiegou; He, Wei; Huang, Wei; Ma, Junting; Yin, Zongsheng

Dopamine delays articular cartilage degradation in osteoarthritis by negative regulation of the NF-κB and JAK2/STAT3 signaling pathways.

Lu, Wei; Ding, Zhenfei; Liu, Fuen; Shan, Wenshan; Cheng, Chao; Xu, Jiegou; He, Wei; Huang, Wei; Ma, Junting; Yin, Zongsheng.

Afiliación

Lu W; Department of Orthopaedics, The First Affiliated Hospital of Anhui Medical University, 218#Ji Xi Road, Hefei, 230032, Anhui, China.
Ding Z; Department of Orthopaedics, The First Affiliated Hospital of Anhui Medical University, 218#Ji Xi Road, Hefei, 230032, Anhui, China.
Liu F; Department of Orthopaedics, The First Affiliated Hospital of Anhui Medical University, 218#Ji Xi Road, Hefei, 230032, Anhui, China.
Shan W; Department of Orthopaedics, The First Affiliated Hospital of Anhui Medical University, 218#Ji Xi Road, Hefei, 230032, Anhui, China.
Cheng C; Department of Orthopaedics, The Fourth Affiliated Hospital of Anhui Medical University, 372#Tun Xi Road, Hefei, 230032, Anhui, China.
Xu J; School of Basic Medical Sciences, Anhui Medical University, 81#Mei Shan Road, Hefei, 230032, Anhui, China.
He W; School of Basic Medical Sciences, Anhui Medical University, 81#Mei Shan Road, Hefei, 230032, Anhui, China.
Huang W; Department of Orthopaedics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, 17#Lu Jiang Road, Hefei, 230001, Anhui, China. Electronic address: ahslyyhwei@126.com.
Ma J; School of Basic Medical Sciences, Anhui Medical University, 81#Mei Shan Road, Hefei, 230032, Anhui, China. Electronic address: majunting@ahmu.edu.cn.
Yin Z; Department of Orthopaedics, The First Affiliated Hospital of Anhui Medical University, 218#Ji Xi Road, Hefei, 230032, Anhui, China. Electronic address: anhuiyzs@126.com.

Biomed Pharmacother ; 119: 109419, 2019 Nov.

Article en En | MEDLINE | ID: mdl-31563117

Asunto(s)

Cartílago Articular/patología; Dopamina/farmacología; Janus Quinasa 2/metabolismo; FN-kappa B/metabolismo; Osteoartritis/metabolismo; Osteoartritis/patología; Factor de Transcripción STAT3/metabolismo; Transducción de Señal; Animales; Cartílago Articular/efectos de los fármacos; Supervivencia Celular/efectos de los fármacos; Condrocitos/efectos de los fármacos; Condrocitos/metabolismo; Condrocitos/patología; Colágeno Tipo II/metabolismo; Ciclooxigenasa 2/metabolismo; Dimetilsulfóxido/farmacología; Modelos Animales de Enfermedad; Humanos; Interleucina-1beta/farmacología; Masculino; Metaloproteinasas de la Matriz/metabolismo; Meniscos Tibiales/efectos de los fármacos; Meniscos Tibiales/patología; Ratones Endogámicos C57BL; Óxido Nítrico Sintasa de Tipo II/metabolismo; Transducción de Señal/efectos de los fármacos

Palabras clave

Chondrocytes; Dopamine; JAK2/STAT3; NF-κB; Osteoarthritis

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Osteoartritis / Transducción de Señal / Dopamina / Cartílago Articular / FN-kappa B / Factor de Transcripción STAT3 / Janus Quinasa 2 Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Biomed Pharmacother Año: 2019 Tipo del documento: Article País de afiliación: China

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