Regulatory T Cell Development in the Thymus.
J Immunol
; 203(8): 2031-2041, 2019 10 15.
Article
en En
| MEDLINE
| ID: mdl-31591259
ABSTRACT
Development of a comprehensive regulatory T (Treg) cell compartment in the thymus is required to maintain immune homeostasis and prevent autoimmunity. In this study, we review cellular and molecular determinants of Treg cell development in the thymus. We focus on the evidence for a self-antigen-focused Treg cell repertoire as well as the APCs responsible for presenting self-antigens to developing thymocytes. We also cover the contribution of different cytokines to thymic Treg development and the cellular populations that produce these cytokines. Finally, we update the originally proposed "two-step" model of thymic Treg differentiation by incorporating new evidence demonstrating that Treg cells develop from two Treg progenitor populations and discuss the functional importance of Treg cells generated via either progenitor pathway.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Timo
/
Linfocitos T Reguladores
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Immunol
Año:
2019
Tipo del documento:
Article