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Conditional targeting in mice reveals that hepatic homogentisate 1,2-dioxygenase activity is essential in reducing circulating homogentisic acid and for effective therapy in the genetic disease alkaptonuria.
Hughes, Juliette H; Liu, Ke; Plagge, Antonius; Wilson, Peter J M; Sutherland, Hazel; Norman, Brendan P; Hughes, Andrew T; Keenan, Craig M; Milan, Anna M; Sakai, Takao; Ranganath, Lakshminarayan R; Gallagher, James A; Bou-Gharios, George.
Afiliación
  • Hughes JH; Institute of Ageing and Chronic disease, University of Liverpool, Liverpool, L7 8TX, UK.
  • Liu K; Institute of Ageing and Chronic disease, University of Liverpool, Liverpool, L7 8TX, UK.
  • Plagge A; Institute of Translational Medicine, University of Liverpool, Liverpool, L69 3GA, UK.
  • Wilson PJM; Institute of Ageing and Chronic disease, University of Liverpool, Liverpool, L7 8TX, UK.
  • Sutherland H; Institute of Ageing and Chronic disease, University of Liverpool, Liverpool, L7 8TX, UK.
  • Norman BP; Institute of Ageing and Chronic disease, University of Liverpool, Liverpool, L7 8TX, UK.
  • Hughes AT; Institute of Ageing and Chronic disease, University of Liverpool, Liverpool, L7 8TX, UK.
  • Keenan CM; Liverpool Clinical Laboratories, Department of Clinical Biochemistry and Metabolic Medicine, Royal Liverpool and Broadgreen University Hospitals Trust, Liverpool, L7 8XP, UK.
  • Milan AM; Institute of Ageing and Chronic disease, University of Liverpool, Liverpool, L7 8TX, UK.
  • Sakai T; Institute of Ageing and Chronic disease, University of Liverpool, Liverpool, L7 8TX, UK.
  • Ranganath LR; Liverpool Clinical Laboratories, Department of Clinical Biochemistry and Metabolic Medicine, Royal Liverpool and Broadgreen University Hospitals Trust, Liverpool, L7 8XP, UK.
  • Gallagher JA; Institute of Translational Medicine, University of Liverpool, Liverpool, L69 3GA, UK.
  • Bou-Gharios G; Institute of Ageing and Chronic disease, University of Liverpool, Liverpool, L7 8TX, UK.
Hum Mol Genet ; 28(23): 3928-3939, 2019 12 01.
Article en En | MEDLINE | ID: mdl-31600782
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Alcaptonuria / Homogentisato 1,2-Dioxigenasa / Ácido Homogentísico / Hígado Límite: Animals Idioma: En Revista: Hum Mol Genet Asunto de la revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Año: 2019 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Alcaptonuria / Homogentisato 1,2-Dioxigenasa / Ácido Homogentísico / Hígado Límite: Animals Idioma: En Revista: Hum Mol Genet Asunto de la revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Año: 2019 Tipo del documento: Article País de afiliación: Reino Unido