De Novo Mutations Reflect Development and Aging of the Human Germline.
Trends Genet
; 35(11): 828-839, 2019 11.
Article
en En
| MEDLINE
| ID: mdl-31610893
ABSTRACT
Human germline de novo mutations (DNMs) are both a driver of evolution and an important cause of genetic diseases. In the past few years, whole-genome sequencing (WGS) of parent-offspring trios has facilitated the large-scale detection and study of human DNMs, which has led to exciting discoveries. The overarching theme of all of these studies is that the DNMs of an individual are a complex mixture of mutations that arise through different biological processes acting at different times during human development and life.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Envejecimiento
/
Mutación de Línea Germinal
/
Células Germinativas
/
Mutación
Límite:
Humans
Idioma:
En
Revista:
Trends Genet
Asunto de la revista:
GENETICA
Año:
2019
Tipo del documento:
Article
País de afiliación:
Países Bajos