Neutrophil elastase contributes to the pathological vascular permeability characteristic of diabetic retinopathy.

Liu, Haitao; Lessieur, Emma M; Saadane, Aicha; Lindstrom, Sarah I; Taylor, Patricia R; Kern, Timothy S

Liu, Haitao; Lessieur, Emma M; Saadane, Aicha; Lindstrom, Sarah I; Taylor, Patricia R; Kern, Timothy S.

Afiliación

Liu H; Department of Biology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Lessieur EM; Department of Ophthalmology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116011, People's Republic of China.
Saadane A; Center for Translational Vision Research, Department of Ophthalmology, Gavin Herbert Eye Institute, School of Medicine, University of California-Irvine, 829 Health Sciences Rd. Gillespie Neuroscience Research Facility, Room 2107, Irvine, CA, 92697, USA.
Lindstrom SI; Center for Translational Vision Research, Department of Ophthalmology, Gavin Herbert Eye Institute, School of Medicine, University of California-Irvine, 829 Health Sciences Rd. Gillespie Neuroscience Research Facility, Room 2107, Irvine, CA, 92697, USA.
Taylor PR; Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH, USA.
Kern TS; Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH, USA.

Diabetologia ; 62(12): 2365-2374, 2019 12.

Article en En | MEDLINE | ID: mdl-31612267

Asunto(s)

Barrera Hematorretinal/metabolismo; Retinopatía Diabética/metabolismo; Elastasa de Leucocito/metabolismo; Retina/metabolismo; Vasos Retinianos/metabolismo; Animales; Barrera Hematorretinal/patología; Permeabilidad Capilar/genética; Diabetes Mellitus Experimental/genética; Diabetes Mellitus Experimental/metabolismo; Diabetes Mellitus Experimental/patología; Retinopatía Diabética/genética; Retinopatía Diabética/patología; Interleucina-17/genética; Interleucina-17/metabolismo; Elastasa de Leucocito/genética; Masculino; Ratones; Ratones Noqueados; Retina/patología; Vasos Retinianos/patología

Palabras clave

Diabetic retinopathy; Elane; IL-17; Neutrophil elastase; Vascular permeability

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Retina / Vasos Retinianos / Barrera Hematorretinal / Elastasa de Leucocito / Retinopatía Diabética Límite: Animals Idioma: En Revista: Diabetologia Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google