Repertoire-wide phylogenetic models of B cell molecular evolution reveal evolutionary signatures of aging and vaccination.

Hoehn, Kenneth B; Vander Heiden, Jason A; Zhou, Julian Q; Lunter, Gerton; Pybus, Oliver G; Kleinstein, Steven H

Hoehn, Kenneth B; Vander Heiden, Jason A; Zhou, Julian Q; Lunter, Gerton; Pybus, Oliver G; Kleinstein, Steven H.

Afiliación

Hoehn KB; Department of Pathology, Yale School of Medicine, New Haven, CT 06520.
Vander Heiden JA; Department of Bioinformatics & Computational Biology, Genentech, South San Francisco, CA 94080.
Zhou JQ; Interdepartmental Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06511.
Lunter G; Wellcome Centre for Human Genetics, Oxford OX3 7BN, United Kingdom.
Pybus OG; Department of Zoology, University of Oxford, Oxford OX1 3PS, United Kingdom oliver.pybus@zoo.ox.ac.uk steven.kleinstein@yale.edu.
Kleinstein SH; Department of Pathology, Yale School of Medicine, New Haven, CT 06520; oliver.pybus@zoo.ox.ac.uk steven.kleinstein@yale.edu.

Proc Natl Acad Sci U S A ; 116(45): 22664-22672, 2019 11 05.

Article en En | MEDLINE | ID: mdl-31636219

Asunto(s)

Envejecimiento/genética; Linfocitos B/inmunología; Evolución Molecular; Filogenia; Vacunación; Humanos; Mutación

Palabras clave

B cell repertoire; BCR; antibody; phylogenetics; somatic hypermutation

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Filogenia / Envejecimiento / Linfocitos B / Vacunación / Evolución Molecular Límite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2019 Tipo del documento: Article

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