Propofol affects mouse embryonic fibroblast survival and proliferation in vitro via ATG5- and calcium-dependent regulation of autophagy.

Xu, Zhen-Dong; Wang, Yong; Liang, Ge; Liu, Zhi-Qiang; Ma, Wu-Hua; Chu, Charleen T; Wei, Hua-Feng

Xu, Zhen-Dong; Wang, Yong; Liang, Ge; Liu, Zhi-Qiang; Ma, Wu-Hua; Chu, Charleen T; Wei, Hua-Feng.

Afiliación

Xu ZD; Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Wang Y; Department of Anesthesiology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, 201204, China.
Liang G; Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Liu ZQ; Department of Anesthesiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510545, China.
Ma WH; Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Chu CT; Department of Anesthesiology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, 201204, China.
Wei HF; Department of Anesthesiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510545, China.

Acta Pharmacol Sin ; 41(3): 303-310, 2020 Mar.

Article en En | MEDLINE | ID: mdl-31645660

Asunto(s)

Anestésicos Intravenosos/farmacología; Proteína 5 Relacionada con la Autofagia/metabolismo; Autofagia/efectos de los fármacos; Calcio/metabolismo; Fibroblastos/efectos de los fármacos; Propofol/farmacología; Animales; Proteína 5 Relacionada con la Autofagia/deficiencia; Proliferación Celular/efectos de los fármacos; Supervivencia Celular/efectos de los fármacos; Células Cultivadas; Relación Dosis-Respuesta a Droga; Ratones; Ratones Noqueados; Relación Estructura-Actividad

Palabras clave

ATG5; InsP3 receptors; autophagy; calcium; mouse embryonic fibroblasts; propofol; ryanodine receptors

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Autofagia / Propofol / Calcio / Anestésicos Intravenosos / Fibroblastos / Proteína 5 Relacionada con la Autofagia Límite: Animals Idioma: En Revista: Acta Pharmacol Sin Asunto de la revista: FARMACOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google