Attenuation of hedgehog/GLI signaling by NT1721 extends survival in pancreatic cancer.

Kowolik, Claudia M; Lin, Min; Xie, Jun; Overman, Larry E; Horne, David A

Kowolik, Claudia M; Lin, Min; Xie, Jun; Overman, Larry E; Horne, David A.

Afiliación

Kowolik CM; Department of Molecular Medicine, City of Hope National Medical Center, 1500 E. Duarte Road, Duarte, CA, 91010, USA.
Lin M; Department of Molecular Medicine, City of Hope National Medical Center, 1500 E. Duarte Road, Duarte, CA, 91010, USA.
Xie J; Department of Molecular Medicine, City of Hope National Medical Center, 1500 E. Duarte Road, Duarte, CA, 91010, USA.
Overman LE; Department of Chemistry, 1102 Natural Sciences II, University of California, Irvine, CA, 92697-2025, USA.
Horne DA; Department of Molecular Medicine, City of Hope National Medical Center, 1500 E. Duarte Road, Duarte, CA, 91010, USA. dhorne@coh.org.

J Exp Clin Cancer Res ; 38(1): 431, 2019 Oct 28.

Article en En | MEDLINE | ID: mdl-31661013

Asunto(s)

Proteínas Hedgehog/metabolismo; Neoplasias Pancreáticas/genética; Proteína con Dedos de Zinc GLI1/metabolismo; Animales; Humanos; Ratones; Neoplasias Pancreáticas/mortalidad; Neoplasias Pancreáticas/patología; Análisis de Supervivencia

Palabras clave

ETP; Epidithiodiketopiperazine; GLI; Hedgehog signaling; Metastasis; NT1721; Orthotopic model; Pancreatic cancer

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Proteínas Hedgehog / Proteína con Dedos de Zinc GLI1 Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Exp Clin Cancer Res Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos

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