The identification and pharmacological evaluation of potent, selective and orally available ACC1 inhibitor.

Mizojiri, Ryo; Asano, Moriteru; Sasaki, Masako; Satoh, Yoshihiko; Yamamoto, Yukiko; Sumi, Hiroyuki; Maezaki, Hironobu

Mizojiri, Ryo; Asano, Moriteru; Sasaki, Masako; Satoh, Yoshihiko; Yamamoto, Yukiko; Sumi, Hiroyuki; Maezaki, Hironobu.

Afiliación

Mizojiri R; Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan. Electronic address: ryo.mizojiri@takeda.com.
Asano M; Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
Sasaki M; Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
Satoh Y; Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
Yamamoto Y; Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
Sumi H; Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
Maezaki H; Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.

Bioorg Med Chem Lett ; 29(23): 126749, 2019 12 01.

Article en En | MEDLINE | ID: mdl-31672259

Asunto(s)

Acetil-CoA Carboxilasa/antagonistas & inhibidores; Animales; Humanos; Ratones

Palabras clave

(14)C acetate uptake inhibition; Acetyl-CoA carboxylase (ACC) 1 inhibitor; Antitumor efficacy; Bioavailability; Malonyl-CoA; Selectivity

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Acetil-CoA Carboxilasa Tipo de estudio: Diagnostic_studies Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2019 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google