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Octyl substituted butenolides from marine-derived Streptomyces koyangensis.
Huang, Hongbo; Song, Yongxiang; Zang, Ruochen; Wang, Xin; Ju, Jianhua.
Afiliación
  • Huang H; CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China.
  • Song Y; School of Oceanology, University of Chinese Academy of Sciences, Beijing, China.
  • Zang R; CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China.
  • Wang X; School of Oceanology, University of Chinese Academy of Sciences, Beijing, China.
  • Ju J; Innovative Marine Drug Screening and Evaluation Center, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China.
Nat Prod Res ; 35(15): 2602-2607, 2021 Aug.
Article en En | MEDLINE | ID: mdl-31691580
A new butenolide derivative (1) featuring octyl substitution at γ-position, together with four known analogues (2-5) were isolated from marine-derived Streptomyces koyangensis SCSIO 5802. The structure of 1 was elucidated by HR-MS and NMR spectroscopic data analyses. The absolute configuration of the stereo centre in lactone ring of 1 was determined by comparison of CD spectrum with those of known compounds. Compound 1 exhibited mild antiviral activity against herpes simplex virus with EC50 value of 25.4 µM.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Streptomyces / 4-Butirolactona / Herpes Simple Idioma: En Revista: Nat Prod Res Año: 2021 Tipo del documento: Article País de afiliación: China
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Streptomyces / 4-Butirolactona / Herpes Simple Idioma: En Revista: Nat Prod Res Año: 2021 Tipo del documento: Article País de afiliación: China