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[Correlation between serum bilirubin and cardiovascular autonomic neuropathy in patients with type 2 diabetes].
Guo, Q Y; Song, W J; Xu, S Y; Zang, P; Lu, B; Gu, P; Shao, J Q.
Afiliación
  • Guo QY; Department of Endocrinology, Jinling Hospital Affiliated to Nanjing University, General Hospital of Eastern Theater Command, Nanjing 210002, China.
Zhonghua Yi Xue Za Zhi ; 99(40): 3132-3138, 2019 Oct 29.
Article en Zh | MEDLINE | ID: mdl-31694103
ABSTRACT

Objective:

To investigate the correlation between serum bilirubin and cardiovascular autonomic neuropathy (CAN) in type 2 diabetes mellitus patients.

Methods:

A total of 369 patients with type 2 diabetes mellitus who were hospitalized at the Department of Endocrinology, Nanjing Jinling Hospital from April 2017 to October 2018 were enrolled, including 226 males and 143 females, with an average age of (54.6±12.1) years. According to cardiovascular reflex tests (CARTs), all the patients were divided into Non CAN group(149 patients without CAN) and CAN group (220 patients complicated with CAN). The difference of serum bilirubin levels between the two groups was compared. The differences of CARTs and the incidence of CAN were compared by tertiles of serum bilirubin levels. The binary logistic regression was used to analyze the risk factors for diabetic cardiovascular autonomic neuropathy.

Results:

The serum total bilirubin [(9.28±2.74) µmol/L vs (11.08±2.98) µmol/L, P<0.001], direct bilirubin [(3.17±1.20) µmol/L vs (3.71±1.24) µmol/L, P<0.001] and indirect bilirubin levels [(6.11±1.89) µmol/L vs (7.37±2.10) µmol/L, P<0.001] in CAN group were significantly lower than that in Non CAN group. With the increase of serum bilirubin, the incidence of CAN decreased (P<0.01). Multivariate Logistic regression analysis showed that serum total bilirubin (OR=0.819, 95%CI 0.744-0.901, P<0.001), direct bilirubin (OR=0.739, 95%CI 0.601-0.908, P=0.004) and indirect bilirubin (OR=0.749, 95%CI 0.653-0.860, P<0.001) were inversely correlated with the incidence of CAN.

Conclusions:

Within the physiological range, lower level of serum bilirubin is inversely correlated with the incidence of CAN. It is noteworthy to screen diabetic cardiovascular autonomic neuropathy in patients with type 2 diabetes mellitus who had a lower serum bilirubin level.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 2 / Neuropatías Diabéticas Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: Zh Revista: Zhonghua Yi Xue Za Zhi Año: 2019 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 2 / Neuropatías Diabéticas Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: Zh Revista: Zhonghua Yi Xue Za Zhi Año: 2019 Tipo del documento: Article País de afiliación: China