Newer perspective on the coupling between glucose-mediated signaling and ß-cell functionality.
Endocr J
; 67(1): 1-8, 2020 Jan 28.
Article
en En
| MEDLINE
| ID: mdl-31694991
ABSTRACT
Insulin secretion by the pancreatic ß-cells is elicited in response to elevated extracellular glucose concentration. In addition to triggering insulin secretion, glucose-induced signal regulates ß-cell proliferation and survival. However, the molecular mechanism underlying the effects of glucose on the ß-cell functionality still remains unclear. Glucokinase, a hexokinase isozyme that catalyzes the phosphorylation of glucose, acts as the glucose sensor in the ß-cells. To investigate the mechanisms of glucose signaling in the regulation of ß-cell functions, we analyzed the role of glucokinase in insulin secretion, ß-cell proliferation and ß-cell apoptosis, using ß-cell-specific glucokinase-haploinsufficient (Gck+/-) mice and allosteric glucokinase activators (GKAs). Glucokinase-mediated glucose metabolism (1) suppresses endoplasmic reticulum (ER) stress-induced ß-cell apoptosis via inducing insulin receptor substrate-2 (IRS-2) expression and expression of ER stress-related molecules, (2) promotes adaptive ß-cell proliferation through activation of the Forkhead Box M1 (FoxM1)/polo-like kinase-1 (PLK1)/centromere protein-A (CENP-A) pathway, (3) induces islet inflammation by promoting interaction of islet-derived S100 calcium-binding protein A8 (S100A8) with macrophages, (4) induces the expression of Fibulin-5 (Fbln5), an extracellular matrix protein to regulate ß-cell functions, and (5) activates other unknown pathways. Glucagon-like peptide-1 (GLP-1) receptor agonists and dipeptidyl peptidase 4 (DPP-4) inhibitors have been found to possibly compensate for dysregulation of glucose metabolism in the ß-cells. This review provides an update and overview of the recent advances in the study of ß-cell pathophysiology and some therapeutic possibilities focusing on glucose-/glucokinase-mediated signaling.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Apoptosis
/
Proliferación Celular
/
Células Secretoras de Insulina
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Secreción de Insulina
/
Glucosa
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Endocr J
Asunto de la revista:
ENDOCRINOLOGIA
Año:
2020
Tipo del documento:
Article
País de afiliación:
Japón