Novel benzimidazole phosphonates as potential inhibitors of protein prenylation.

Bhuiyan, Nazmul H; Varney, Michelle L; Wiemer, David F; Holstein, Sarah A

Bhuiyan, Nazmul H; Varney, Michelle L; Wiemer, David F; Holstein, Sarah A.

Afiliación

Bhuiyan NH; Department of Chemistry, University of Iowa, Iowa City, IA 52242-1294, USA.
Varney ML; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Wiemer DF; Department of Chemistry, University of Iowa, Iowa City, IA 52242-1294, USA; Department of Pharmacology, University of Iowa, Iowa City, IA 52242-1109, USA.
Holstein SA; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA. Electronic address: sarah.holstein@unmc.edu.

Bioorg Med Chem Lett ; 29(24): 126757, 2019 12 15.

Article en En | MEDLINE | ID: mdl-31699606

Asunto(s)

Bencimidazoles/antagonistas & inhibidores; Bencimidazoles/uso terapéutico; Organofosfonatos/antagonistas & inhibidores; Organofosfonatos/uso terapéutico; Prenilación de Proteína/efectos de los fármacos; Bencimidazoles/farmacología; Humanos; Organofosfonatos/farmacología

Palabras clave

Benzimidazole; Bisphosphonate; Carboxyphosphonate; Farnesyl diphosphate synthase; Geranylgeranyl transferase II; Inhibition; Isoprenoid biosynthesis

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Bencimidazoles / Prenilación de Proteína / Organofosfonatos Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos

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