Change in visual acuity and retinal structures following Repository Corticotropin Injection (RCI) therapy in patients with acute demyelinating optic neuritis: Improvement in low contrast visual acuity in both affected and contralateral eyes in a single-armed open-label study.
J Neurol Sci
; 407: 116505, 2019 Dec 15.
Article
en En
| MEDLINE
| ID: mdl-31706456
ABSTRACT
BACKGROUND:
Current treatments after an episode of optic neuritis have limited success protecting the retinal nerves and restoring visual function.OBJECTIVE:
To assess the effectiveness of Repository Corticotropin Injection (RCI) after the onset of optic neuritis.METHODS:
Twenty-four adults were treated with RCI within 2â¯weeks of symptom onset. Seven exams over 400â¯days measured low- and high-contrast visual acuity (LCVA and HCVA) and spectral domain optical coherence tomography of the retinal structures. Differences between and among affected and contralateral eyes were assessed using linear mixed models.RESULTS:
HCVA improved in the affected eye over the study (36.2 letters to 52.5), and LCVA improved in both the affected eye (1.8 letters to 6.8) and the contralateral eye (8.3 letters to 11.7). These functional improvements occurred concurrent to a thinning in the papillomacular bundle and the ganglion cell, inner plexiform, and retinal nerve fiber layers, while the inner nuclear, outer plexiform, outer nuclear, and photoreceptor layers thickened.CONCLUSION:
The eyes affected by the ON and treated with RCI improved in both LCVA and HCVA, and unexpectedly LCVA improved in the contralateral eye as well. This functional improvement was mirrored by structural changes in the retina. This study lays the groundwork for future studies to explore potential neuro-protective and neuro-restorative effects of RCI.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Retina
/
Agudeza Visual
/
Neuritis Óptica
/
Hormona Adrenocorticotrópica
Límite:
Adult
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
J Neurol Sci
Año:
2019
Tipo del documento:
Article
País de afiliación:
Estados Unidos