Muscle to Brain Partitioning as Measure of Transporter-Mediated Efflux at the Rat Blood-Brain Barrier and Its Implementation into Compound Optimization in Drug Discovery.

Cui, Yunhai; Lotz, Ralf; Rapp, Hermann; Klinder, Klaus; Himstedt, Anneke; Sauer, Achim

Cui, Yunhai; Lotz, Ralf; Rapp, Hermann; Klinder, Klaus; Himstedt, Anneke; Sauer, Achim.

Afiliación

Cui Y; Department of Drug Discovery Sciences, Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach, Germany.
Lotz R; Department of Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach, Germany.
Rapp H; Department of Drug Discovery Sciences, Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach, Germany.
Klinder K; Department of Drug Discovery Sciences, Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach, Germany.
Himstedt A; Department of Drug Discovery Sciences, Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach, Germany.
Sauer A; Department of Clinical Pharmacy, Institute of Pharmacy, University of Hamburg, 20146 Hamburg, Germany.

Pharmaceutics ; 11(11)2019 Nov 11.

Article en En | MEDLINE | ID: mdl-31718023

Palabras clave

BCRP, efflux, Kp,uu,brain, drug partitioning, CNS drug, screening, drug discovery, in vitroin vivo correlation; P-gp; bloodbrain barrier

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Pharmaceutics Año: 2019 Tipo del documento: Article País de afiliación: Alemania

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