Prophylactic breast irradiation reduces background parenchymal enhancement (BPE) on MRI: A secondary analysis.

Ben-David, Merav A; Corn, Benjamin W; Evron, Ella; Goldberg, Hadassah; Pfeffer, Raphael M; Abdah-Bortnyak, Roxoliana; Matceyevsky, Dianna; Weinstein, Yuliana; Golan, Orit; Sklair-Levy, Miri

Ben-David, Merav A; Corn, Benjamin W; Evron, Ella; Goldberg, Hadassah; Pfeffer, Raphael M; Abdah-Bortnyak, Roxoliana; Matceyevsky, Dianna; Weinstein, Yuliana; Golan, Orit; Sklair-Levy, Miri.

Afiliación

Ben-David MA; Department of Radiation Oncology, Sheba Medical Center, Ramat-Gan, Israel; Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel.
Corn BW; Shaare Zedek Medical Center, Jerusalem, Israel; Hadassah Medical School, The Hebrew University, Jerusalem, Israel. Electronic address: ben.w.corn@gmail.com.
Evron E; Oncology, Kaplan Medical Institute, Rehovot, Israel; Hadassah Medical School, The Hebrew University, Jerusalem, Israel.
Goldberg H; Oncology Institute, Galilee Medical Center, Naharia, Israel.
Pfeffer RM; Assuta Medical Center, Tel Aviv, Israel.
Abdah-Bortnyak R; Oncology Division, Rambam Health Care Campus, Rappaport Faculty of Medicine, Technion, Haifa, Israel.
Matceyevsky D; Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.
Weinstein Y; Assuta Medical Center, Tel Aviv, Israel.
Golan O; Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.
Sklair-Levy M; Department of Radiation Oncology, Sheba Medical Center, Ramat-Gan, Israel; Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel.

Breast ; 49: 70-73, 2020 Feb.

Article en En | MEDLINE | ID: mdl-31734591

ABSTRACT

ABSTRACT

PURPOSE:

We recently showed that prophylactic breast irradiation (PBI) reduces the risk of contralateral breast cancer in BRCA mutation carriers undergoing treatment for early breast cancer. It has been suggested that Background Parenchymal Enhancement (BPE) may be a biomarker for increased risk of breast cancer.

METHODS:

For participants in the trial we reviewed the MRI prior to enrollment and following radiation treatment and scored the contralateral breast for BPE and density.

RESULTS:

Significant reduction of BPE was more commonly noted following PBI (pâ¯=â¯0.011) compared to the control group.

CONCLUSION:

Reduction of BPE by PBI may contribute to its prophylactic effect.

Asunto(s)

Neoplasias de la Mama/prevención & control; Aumento de la Imagen/métodos; Imagen por Resonancia Magnética/estadística & datos numéricos; Tejido Parenquimatoso/efectos de la radiación; Radioterapia/métodos; Adulto; Anciano; Proteína BRCA1; Proteína BRCA2; Biomarcadores de Tumor/efectos de la radiación; Mama/diagnóstico por imagen; Mama/efectos de la radiación; Neoplasias de la Mama/genética; Femenino; Predisposición Genética a la Enfermedad/prevención & control; Humanos; Persona de Mediana Edad; Mutación; Tejido Parenquimatoso/diagnóstico por imagen

Palabras clave

BPE; BRCA; Breast cancer; Prophylactic breast irradiation

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Radioterapia / Neoplasias de la Mama / Imagen por Resonancia Magnética / Aumento de la Imagen / Tejido Parenquimatoso Tipo de estudio: Clinical_trials Límite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Breast Asunto de la revista: ENDOCRINOLOGIA / NEOPLASIAS Año: 2020 Tipo del documento: Article País de afiliación: Israel

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