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Site-Specific Conjugation of the Indolinobenzodiazepine DGN549 to Antibodies Affords Antibody-Drug Conjugates with an Improved Therapeutic Index as Compared with Lysine Conjugation.
Bai, Chen; Reid, Emily E; Wilhelm, Alan; Shizuka, Manami; Maloney, Erin K; Laleau, Rassol; Harvey, Lauren; Archer, Katie E; Vitharana, Dilrukshi; Adams, Sharlene; Kovtun, Yelena; Miller, Michael L; Chari, Ravi; Keating, Thomas A; Yoder, Nicholas C.
Afiliación
  • Bai C; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States.
  • Reid EE; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States.
  • Wilhelm A; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States.
  • Shizuka M; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States.
  • Maloney EK; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States.
  • Laleau R; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States.
  • Harvey L; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States.
  • Archer KE; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States.
  • Vitharana D; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States.
  • Adams S; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States.
  • Kovtun Y; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States.
  • Miller ML; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States.
  • Chari R; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States.
  • Keating TA; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States.
  • Yoder NC; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States.
Bioconjug Chem ; 31(1): 93-103, 2020 01 15.
Article en En | MEDLINE | ID: mdl-31747250
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Benzodiazepinas / Inmunoconjugados / Antineoplásicos Inmunológicos / Oxindoles / Lisina / Neoplasias Límite: Animals / Female / Humans Idioma: En Revista: Bioconjug Chem Asunto de la revista: BIOQUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Benzodiazepinas / Inmunoconjugados / Antineoplásicos Inmunológicos / Oxindoles / Lisina / Neoplasias Límite: Animals / Female / Humans Idioma: En Revista: Bioconjug Chem Asunto de la revista: BIOQUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos