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Are Biotransformation Studies of Therapeutic Proteins Needed? Scientific Considerations and Technical Challenges.
Schadt, Simone; Hauri, Simon; Lopes, Filipe; Edelmann, Martin R; Staack, Roland F; Villaseñor, Roberto; Kettenberger, Hubert; Roth, Adrian B; Schuler, Franz; Richter, Wolfgang F; Funk, Christoph.
Afiliación
  • Schadt S; Roche Pharma Research and Early Development, Pharmaceutical Sciences (S.S., S.H., F.L., R.V., A.B.R., F.S., W.F.R., C.F.) and Roche Pharma Research and Early Development, Therapeutic Modalities (M.R.E.), Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland; and Roche Pharma Resear
  • Hauri S; Roche Pharma Research and Early Development, Pharmaceutical Sciences (S.S., S.H., F.L., R.V., A.B.R., F.S., W.F.R., C.F.) and Roche Pharma Research and Early Development, Therapeutic Modalities (M.R.E.), Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland; and Roche Pharma Resear
  • Lopes F; Roche Pharma Research and Early Development, Pharmaceutical Sciences (S.S., S.H., F.L., R.V., A.B.R., F.S., W.F.R., C.F.) and Roche Pharma Research and Early Development, Therapeutic Modalities (M.R.E.), Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland; and Roche Pharma Resear
  • Edelmann MR; Roche Pharma Research and Early Development, Pharmaceutical Sciences (S.S., S.H., F.L., R.V., A.B.R., F.S., W.F.R., C.F.) and Roche Pharma Research and Early Development, Therapeutic Modalities (M.R.E.), Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland; and Roche Pharma Resear
  • Staack RF; Roche Pharma Research and Early Development, Pharmaceutical Sciences (S.S., S.H., F.L., R.V., A.B.R., F.S., W.F.R., C.F.) and Roche Pharma Research and Early Development, Therapeutic Modalities (M.R.E.), Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland; and Roche Pharma Resear
  • Villaseñor R; Roche Pharma Research and Early Development, Pharmaceutical Sciences (S.S., S.H., F.L., R.V., A.B.R., F.S., W.F.R., C.F.) and Roche Pharma Research and Early Development, Therapeutic Modalities (M.R.E.), Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland; and Roche Pharma Resear
  • Kettenberger H; Roche Pharma Research and Early Development, Pharmaceutical Sciences (S.S., S.H., F.L., R.V., A.B.R., F.S., W.F.R., C.F.) and Roche Pharma Research and Early Development, Therapeutic Modalities (M.R.E.), Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland; and Roche Pharma Resear
  • Roth AB; Roche Pharma Research and Early Development, Pharmaceutical Sciences (S.S., S.H., F.L., R.V., A.B.R., F.S., W.F.R., C.F.) and Roche Pharma Research and Early Development, Therapeutic Modalities (M.R.E.), Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland; and Roche Pharma Resear
  • Schuler F; Roche Pharma Research and Early Development, Pharmaceutical Sciences (S.S., S.H., F.L., R.V., A.B.R., F.S., W.F.R., C.F.) and Roche Pharma Research and Early Development, Therapeutic Modalities (M.R.E.), Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland; and Roche Pharma Resear
  • Richter WF; Roche Pharma Research and Early Development, Pharmaceutical Sciences (S.S., S.H., F.L., R.V., A.B.R., F.S., W.F.R., C.F.) and Roche Pharma Research and Early Development, Therapeutic Modalities (M.R.E.), Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland; and Roche Pharma Resear
  • Funk C; Roche Pharma Research and Early Development, Pharmaceutical Sciences (S.S., S.H., F.L., R.V., A.B.R., F.S., W.F.R., C.F.) and Roche Pharma Research and Early Development, Therapeutic Modalities (M.R.E.), Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland; and Roche Pharma Resear
Drug Metab Dispos ; 47(12): 1443-1456, 2019 12.
Article en En | MEDLINE | ID: mdl-31748266
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Preparaciones Farmacéuticas / Proteínas / Bibliotecas de Moléculas Pequeñas Tipo de estudio: Guideline Límite: Animals / Humans Idioma: En Revista: Drug Metab Dispos Asunto de la revista: FARMACOLOGIA Año: 2019 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Preparaciones Farmacéuticas / Proteínas / Bibliotecas de Moléculas Pequeñas Tipo de estudio: Guideline Límite: Animals / Humans Idioma: En Revista: Drug Metab Dispos Asunto de la revista: FARMACOLOGIA Año: 2019 Tipo del documento: Article