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Clinicopathological characteristics of dysplastic teratomous neuroglia with anti-N-methyl-d-aspartate receptor encephalitis.
Xiao, Yangyang; Li, Jian; Liu, Lingjuan; Xiong, Jie; Xu, Jie; Liang, Qingchun; She, Xiaoling; Tan, Hong; Ma, Yong; Mao, Ding'an; Liu, Liqun.
Afiliación
  • Xiao Y; Department of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, China.; Department of Pediatrics Neurology, Children's Medical Center, The Second Xiangya Hospital, Central South University, Changsha, China.
  • Li J; Department of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, China.; Department of Pediatrics Neurology, Children's Medical Center, The Second Xiangya Hospital, Central South University, Changsha, China.
  • Liu L; Department of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, China.; Department of Pediatrics Neurology, Children's Medical Center, The Second Xiangya Hospital, Central South University, Changsha, China.
  • Xiong J; Department of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, China.; Department of Pediatrics Neurology, Children's Medical Center, The Second Xiangya Hospital, Central South University, Changsha, China.
  • Xu J; Department of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, China.; Department of Pediatrics Neurology, Children's Medical Center, The Second Xiangya Hospital, Central South University, Changsha, China.
  • Liang Q; Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, China.
  • She X; Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, China.
  • Tan H; Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, China.
  • Ma Y; Department of General Surgery, The Second Xiangya Hospital, Central South University, Changsha, China.
  • Mao D; Department of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, China.; Department of Pediatrics Neurology, Children's Medical Center, The Second Xiangya Hospital, Central South University, Changsha, China.
  • Liu L; Department of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, China.; Department of Pediatrics Neurology, Children's Medical Center, The Second Xiangya Hospital, Central South University, Changsha, China. Electronic address: liuliqun@csu.edu.cn.
Clin Immunol ; 210: 108271, 2020 01.
Article en En | MEDLINE | ID: mdl-31756658
ABSTRACT
In this study, we investigated whether unique pathological characteristics exist in teratomas that can trigger autoimmune anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis. We compared a case of retroperitoneal teratoma associated with anti-NMDAR encephalitis and four control cases. The encephalitis-positive case showed that (i) more dysplastic neuroglia with higher Ki-67 labeling index values than the control cases, which met the diagnostic criteria of astrocytoma, (ii) the NMDAR subunit NR1 was expressed more abundantly in neuroglial tissue where many neuroglial cells co-expressed glial fibrillary acidic protein (GFAP) and NR1 and formed abnormally large cellular masses, (iii) intense NR1 expression occurs in squamous epithelium near neuroglial tissue and lymphocyte infiltration. This study showed that dysplastic neuroglial tissue resembling central nervous system tumors, which might promote autoimmunity, distinguished the case with NMDAR encephalitis from the controls. Additionally, abnormal expression of NR1 occurs in non-neural tissues and could be triggered by inflammation and participate in autoimmunity.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neuroglía / Receptores de N-Metil-D-Aspartato / Encefalitis Antirreceptor N-Metil-D-Aspartato / Lesiones Intraepiteliales Escamosas Límite: Adult / Child / Female / Humans / Infant / Male / Newborn Idioma: En Revista: Clin Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: China
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neuroglía / Receptores de N-Metil-D-Aspartato / Encefalitis Antirreceptor N-Metil-D-Aspartato / Lesiones Intraepiteliales Escamosas Límite: Adult / Child / Female / Humans / Infant / Male / Newborn Idioma: En Revista: Clin Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: China