Establishing a new human hypertrophic cardiomyopathy-specific model using human embryonic stem cells.

Cai, Huanhuan; Li, Bin; Bai, Aobing; Huang, Jie; Zhan, Yongkun; Sun, Ning; Liang, Qianqian; Xu, Chen

Cai, Huanhuan; Li, Bin; Bai, Aobing; Huang, Jie; Zhan, Yongkun; Sun, Ning; Liang, Qianqian; Xu, Chen.

Afiliación

Cai H; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China; Department of Cardiologyï¼Zhongnan Hosipital of Wuhan Universityï¼Wuhanï¼430071ï¼China.
Li B; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Bai A; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Huang J; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Zhan Y; Children's Hospital, Fudan University, Shanghai, 201102, China.
Sun N; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Liang Q; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China. Electronic address: liangqianqian@fudan.edu.cn.
Xu C; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China. Electronic address: xu_chen85@fudan.edu.cn.

Exp Cell Res ; 387(1): 111736, 2020 02 01.

Article en En | MEDLINE | ID: mdl-31759053

Asunto(s)

Cardiomiopatía Hipertrófica/patología; Células Madre Embrionarias Humanas/citología; Cardiomiopatía Hipertrófica/metabolismo; Línea Celular; Células HEK293; Células Madre Embrionarias Humanas/metabolismo; Humanos; Hipertrofia/metabolismo; Hipertrofia/patología; Mutación/genética; Miocitos Cardíacos/citología; Miocitos Cardíacos/metabolismo; Cadenas Pesadas de Miosina/metabolismo; Fenotipo; Troponina T/metabolismo

Palabras clave

Cardiac troponin T; Human embryonic stem cells; Hypertrophic cardiomyopathy; R92Q mutation; TALEN

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Cardiomiopatía Hipertrófica / Células Madre Embrionarias Humanas Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Exp Cell Res Año: 2020 Tipo del documento: Article

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