Hemistepsin A alleviates liver fibrosis by inducing apoptosis of activated hepatic stellate cells via inhibition of nuclear factor-&#954;B and Akt.

Kim, Jae Kwang; Han, Nu Ri; Park, Sang Mi; Jegal, Kyung Hwan; Jung, Ji Yun; Jung, Eun Hye; Kim, Eun Ok; Kim, Doyeon; Jung, Dae Hwa; Lee, Jong Rok; Park, Chung A; Ku, Sae Kwang; Cho, Il Je; Kim, Sang Chan

Hemistepsin A alleviates liver fibrosis by inducing apoptosis of activated hepatic stellate cells via inhibition of nuclear factor-κB and Akt.

Kim, Jae Kwang; Han, Nu Ri; Park, Sang Mi; Jegal, Kyung Hwan; Jung, Ji Yun; Jung, Eun Hye; Kim, Eun Ok; Kim, Doyeon; Jung, Dae Hwa; Lee, Jong Rok; Park, Chung A; Ku, Sae Kwang; Cho, Il Je; Kim, Sang Chan.

Afiliación

Kim JK; College of Korean Medicine, Daegu Haany University, Gyeongsan, Gyeongsangbuk-do, 38610, Republic of Korea.
Han NR; College of Korean Medicine, Daegu Haany University, Gyeongsan, Gyeongsangbuk-do, 38610, Republic of Korea.
Park SM; College of Korean Medicine, Daegu Haany University, Gyeongsan, Gyeongsangbuk-do, 38610, Republic of Korea.
Jegal KH; College of Korean Medicine, Daegu Haany University, Gyeongsan, Gyeongsangbuk-do, 38610, Republic of Korea; College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea.
Jung JY; College of Korean Medicine, Daegu Haany University, Gyeongsan, Gyeongsangbuk-do, 38610, Republic of Korea.
Jung EH; College of Korean Medicine, Daegu Haany University, Gyeongsan, Gyeongsangbuk-do, 38610, Republic of Korea.
Kim EO; College of Korean Medicine, Daegu Haany University, Gyeongsan, Gyeongsangbuk-do, 38610, Republic of Korea.
Kim D; College of Korean Medicine, Daegu Haany University, Gyeongsan, Gyeongsangbuk-do, 38610, Republic of Korea.
Jung DH; Hani Bio Co., Ltd, 142 Yulam-ro, Daegu, 41059, Republic of Korea.
Lee JR; Department of Pharmaceutical Engineering, College of Bio-technology, Daegu Haany University, Gyeongsan, Gyeongsangbuk-do, 38610, Republic of Korea.
Park CA; College of Korean Medicine, Daegu Haany University, Gyeongsan, Gyeongsangbuk-do, 38610, Republic of Korea.
Ku SK; College of Korean Medicine, Daegu Haany University, Gyeongsan, Gyeongsangbuk-do, 38610, Republic of Korea.
Cho IJ; College of Korean Medicine, Daegu Haany University, Gyeongsan, Gyeongsangbuk-do, 38610, Republic of Korea. Electronic address: skek023@dhu.ac.kr.
Kim SC; College of Korean Medicine, Daegu Haany University, Gyeongsan, Gyeongsangbuk-do, 38610, Republic of Korea. Electronic address: sckim@dhu.ac.kr.

Food Chem Toxicol ; 135: 111044, 2020 Jan.

Article en En | MEDLINE | ID: mdl-31830547

Asunto(s)

Apoptosis/efectos de los fármacos; Células Estrelladas Hepáticas/efectos de los fármacos; Lactonas/farmacología; Cirrosis Hepática/prevención & control; Sesquiterpenos/farmacología; Animales; Línea Celular Transformada; Cloroformo/farmacología; Células Estrelladas Hepáticas/metabolismo; Humanos; Cirrosis Hepática/metabolismo; Cirrosis Hepática/patología; Ratones; FN-kappa B/metabolismo; Extractos Vegetales/farmacología; Proteínas Proto-Oncogénicas c-akt/antagonistas & inhibidores; Proteínas Proto-Oncogénicas c-akt/metabolismo; Transducción de Señal/efectos de los fármacos

Palabras clave

Akt; Hemistepsin A (HsA); Hepatic stellate cell (HSC); Liver fibrosis; Nuclear factor-κB (NF-κB)

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Sesquiterpenos / Apoptosis / Células Estrelladas Hepáticas / Lactonas / Cirrosis Hepática Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Food Chem Toxicol Año: 2020 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google