Harmonic Motion Imaging of Pancreatic Tumor Stiffness Indicates Disease State and Treatment Response.
Clin Cancer Res
; 26(6): 1297-1308, 2020 03 15.
Article
en En
| MEDLINE
| ID: mdl-31831559
ABSTRACT
PURPOSE:
Pancreatic ductal adenocarcinoma (PDA) is a common, deadly cancer that is challenging both to diagnose and to manage. Its hallmark is an expansive, desmoplastic stroma characterized by high mechanical stiffness. In this study, we sought to leverage this feature of PDA for twopurposes:
differential diagnosis and monitoring of response to treatment. EXPERIMENTALDESIGN:
Harmonic motion imaging (HMI) is a functional ultrasound technique that yields a quantitative relative measurement of stiffness suitable for comparisons between individuals and over time. We used HMI to quantify pancreatic stiffness in mouse models of pancreatitis and PDA as well as in a series of freshly resected human pancreatic cancer specimens.RESULTS:
In mice, we learned that stiffness increased during progression from preneoplasia to adenocarcinoma and also effectively distinguished PDA from several forms of pancreatitis. In human specimens, the distinction of tumors versus adjacent pancreatitis or normal pancreas tissue was even more stark. Moreover, in both mice and humans, stiffness increased in proportion to tumor size, indicating that tuning of mechanical stiffness is an ongoing process during tumor progression. Finally, using a brca2-mutant mouse model of PDA that is sensitive to cisplatin, we found that tissue stiffness decreases when tumors respond successfully to chemotherapy. Consistent with this observation, we found that tumor tissues from patients who had undergone neoadjuvant therapy were less stiff than those of untreated patients.CONCLUSIONS:
These findings support further development of HMI for clinical applications in disease staging and treatment response assessment in PDA.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Pancreáticas
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Procesamiento de Señales Asistido por Computador
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Ultrasonografía
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Fantasmas de Imagen
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Diagnóstico por Imagen de Elasticidad
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Aged
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Aged80
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Animals
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Clin Cancer Res
Asunto de la revista:
NEOPLASIAS
Año:
2020
Tipo del documento:
Article