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Kinetic and structural studies of Trypanosoma and Leishmania phosphofructokinases show evolutionary divergence and identify AMP as a switch regulating glycolysis versus gluconeogenesis.
Fernandes, Peter M; Kinkead, James; McNae, Iain W; Vásquez-Valdivieso, Monserrat; Wear, Martin A; Michels, Paul A M; Walkinshaw, Malcolm D.
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  • Fernandes PM; Centre for Translational and Chemical Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh, UK.
  • Kinkead J; Centre for Translational and Chemical Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh, UK.
  • McNae IW; Centre for Translational and Chemical Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh, UK.
  • Vásquez-Valdivieso M; Centre for Translational and Chemical Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh, UK.
  • Wear MA; Centre for Translational and Chemical Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh, UK.
  • Michels PAM; Centre for Translational and Chemical Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh, UK.
  • Walkinshaw MD; Centre for Translational and Chemical Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh, UK.
FEBS J ; 287(13): 2847-2861, 2020 07.
Article en En | MEDLINE | ID: mdl-31838765
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Trypanosoma brucei brucei / Adenosina Monofosfato / Fosfofructoquinasas / Glucólisis / Guanosina Trifosfato / Leishmania Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: FEBS J Asunto de la revista: BIOQUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Trypanosoma brucei brucei / Adenosina Monofosfato / Fosfofructoquinasas / Glucólisis / Guanosina Trifosfato / Leishmania Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: FEBS J Asunto de la revista: BIOQUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido