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Enhanced amyloid-ß generation by γ-secretase complex in DRM microdomains with reduced cholesterol levels.
Hata, Saori; Hu, Anqi; Piao, Yi; Nakaya, Tadashi; Taru, Hidenori; Morishima-Kawashima, Maho; Murayama, Shigeo; Nishimura, Masaki; Suzuki, Toshiharu.
Afiliación
  • Hata S; Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
  • Hu A; Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
  • Piao Y; Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
  • Nakaya T; Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
  • Taru H; Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
  • Morishima-Kawashima M; Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
  • Murayama S; Department of Molecular Neuropathology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
  • Nishimura M; Department of Neuropathology, Tokyo Metropolitan Institute of Gerontology, Tokyo 173-0015, Japan.
  • Suzuki T; Molecular Neuroscience Research Center, Shiga University of Medical Science, Shiga 520-2192, Japan.
Hum Mol Genet ; 29(3): 382-393, 2020 02 01.
Article en En | MEDLINE | ID: mdl-31841137
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Encéfalo / Colesterol / Péptidos beta-Amiloides / Microdominios de Membrana / Secretasas de la Proteína Precursora del Amiloide / Enfermedad de Alzheimer Tipo de estudio: Observational_studies Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Hum Mol Genet Asunto de la revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Año: 2020 Tipo del documento: Article País de afiliación: Japón
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Encéfalo / Colesterol / Péptidos beta-Amiloides / Microdominios de Membrana / Secretasas de la Proteína Precursora del Amiloide / Enfermedad de Alzheimer Tipo de estudio: Observational_studies Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Hum Mol Genet Asunto de la revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Año: 2020 Tipo del documento: Article País de afiliación: Japón