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Structure and dynamics of lipid membranes interacting with antivirulence end-phosphorylated polyethylene glycol block copolymers.
Yu, Jing; Mao, Jun; Nagao, Michihiro; Bu, Wei; Lin, Binhua; Hong, Kunlun; Jiang, Zhang; Liu, Yun; Qian, Shuo; Tirrell, Matthew; Chen, Wei.
Afiliación
  • Yu J; Centre for Molecular Engineering and Materials Science Division, Argonne National Laboratory, Lemont, IL 60439, USA. wchen@anl.gov and Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, USA. mtirrell@uchicago.edu.
  • Mao J; Centre for Molecular Engineering and Materials Science Division, Argonne National Laboratory, Lemont, IL 60439, USA. wchen@anl.gov and Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, USA. mtirrell@uchicago.edu.
  • Nagao M; NIST Centre for Neutron Research, National Institute of Standards and Technology, Gaithersburg, MD 20899-6102, USA and Centre for Exploration of Energy and Matter, Indiana University, Bloomington, IN 47408, USA.
  • Bu W; Centre for Advanced Radiation Sources, University of Chicago, Chicago, IL 60637, USA.
  • Lin B; Centre for Advanced Radiation Sources, University of Chicago, Chicago, IL 60637, USA and James Franck Institute, University of Chicago, Chicago, IL 60637, USA.
  • Hong K; Centre for Nanophase Materials Sciences, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA.
  • Jiang Z; Advanced Photon Source, Argonne National Laboratory, Lemont, IL 60439, USA.
  • Liu Y; NIST Centre for Neutron Research, National Institute of Standards and Technology, Gaithersburg, MD 20899-6102, USA and Department of Chemical and Biomolecular Engineering, Centre for Neutron Science, University of Delaware, Newark, DE 19716, USA.
  • Qian S; Biology and Soft Matter Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA.
  • Tirrell M; Centre for Molecular Engineering and Materials Science Division, Argonne National Laboratory, Lemont, IL 60439, USA. wchen@anl.gov and Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, USA. mtirrell@uchicago.edu.
  • Chen W; Centre for Molecular Engineering and Materials Science Division, Argonne National Laboratory, Lemont, IL 60439, USA. wchen@anl.gov and Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, USA. mtirrell@uchicago.edu.
Soft Matter ; 16(4): 983-989, 2020 Jan 28.
Article en En | MEDLINE | ID: mdl-31851201
The structure and dynamics of lipid membranes in the presence of extracellular macromolecules are critical for cell membrane functions and many pharmaceutical applications. The pathogen virulence-suppressing end-phosphorylated polyethylene glycol (PEG) triblock copolymer (Pi-ABAPEG) markedly changes the interactions with lipid vesicle membranes and prevents PEG-induced vesicle phase separation in contrast to the unphosphorylated copolymer (ABAPEG). Pi-ABAPEG weakly absorbs on the surface of lipid vesicle membranes and slightly changes the structure of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) unilamellar vesicles at 37 °C, as evidenced by small angle neutron scattering. X-ray reflectivity measurements confirm the weak adsorption of Pi-ABAPEG on DMPC monolayer, resulting in a more compact DMPC monolayer structure. Neutron spin-echo results show that the adsorption of Pi-ABAPEG on DMPC vesicle membranes increases the membrane bending modulus κ.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fosfatidilcolinas / Membrana Celular / Membrana Dobles de Lípidos / Lípidos de la Membrana Límite: Humans Idioma: En Revista: Soft Matter Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fosfatidilcolinas / Membrana Celular / Membrana Dobles de Lípidos / Lípidos de la Membrana Límite: Humans Idioma: En Revista: Soft Matter Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos