Isoquinolines from national herb Corydalis tomentella and neuroprotective effect against lipopolysaccharide-induced BV2 microglia cells.
Bioorg Chem
; 95: 103489, 2020 01.
Article
en En
| MEDLINE
| ID: mdl-31862456
ABSTRACT
Five new isoquinolines (1-5) were isolated from national herb Corydalis tomentella. Their structures were elucidated by extensive analysis of the 1D and 2D NMR spectra and from the HRESIMS. Absolute configurations of 1-3 were determined by comparing their experimental and computed ECD data. Since plants from Corydalis have been reported to protect against Alzheimer's disease, all compounds were evaluated for their neuroprotective effect against lipopolysaccharide-induced BV2 microglia cells. Compound 2 and 3 showed well anti-neuroinflammatory activity at low concentration (25 µM).
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Lipopolisacáridos
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Microglía
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Fármacos Neuroprotectores
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Corydalis
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Enfermedad de Alzheimer
/
Isoquinolinas
Límite:
Animals
Idioma:
En
Revista:
Bioorg Chem
Año:
2020
Tipo del documento:
Article