Oxyberberine, a novel gut microbiota-mediated metabolite of berberine, possesses superior anti-colitis effect: Impact on intestinal epithelial barrier, gut microbiota profile and TLR4-MyD88-NF-&#954;B pathway.

Li, Cailan; Ai, Gaoxiang; Wang, Yongfu; Lu, Qiang; Luo, Chaodan; Tan, Lihua; Lin, Guosheng; Liu, Yuhong; Li, Yucui; Zeng, Huifang; Chen, Jiannan; Lin, Zhixiu; Xian, Yanfang; Huang, Xiaoqi; Xie, Jianhui; Su, Ziren

Oxyberberine, a novel gut microbiota-mediated metabolite of berberine, possesses superior anti-colitis effect: Impact on intestinal epithelial barrier, gut microbiota profile and TLR4-MyD88-NF-κB pathway.

Li, Cailan; Ai, Gaoxiang; Wang, Yongfu; Lu, Qiang; Luo, Chaodan; Tan, Lihua; Lin, Guosheng; Liu, Yuhong; Li, Yucui; Zeng, Huifang; Chen, Jiannan; Lin, Zhixiu; Xian, Yanfang; Huang, Xiaoqi; Xie, Jianhui; Su, Ziren.

Afiliación

Li C; Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510006, PR China; Department of Pharmacology, Zunyi Medical University, Zhuhai Campus, Zhuhai, 5190
Ai G; Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510006, PR China.
Wang Y; Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510006, PR China; The First Affiliated Hospital of Chinese Medicine, Guangzhou University of Chines
Lu Q; Department of Pharmaceutical Sciences, Zunyi Medical University, Zhuhai Campus, Zhuhai, 519041, PR China.
Luo C; Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510006, PR China.
Tan L; Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510006, PR China; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chines
Lin G; Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510006, PR China.
Liu Y; Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510006, PR China.
Li Y; Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510006, PR China.
Zeng H; The First Affiliated Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510405, PR China.
Chen J; Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510006, PR China.
Lin Z; School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, PR China.
Xian Y; School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, PR China.
Huang X; Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510006, PR China.
Xie J; Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, 510120, PR China; Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome,
Su Z; Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510006, PR China. Electronic address: suziren@gzucm.edu.cn.

Pharmacol Res ; 152: 104603, 2020 02.

Article en En | MEDLINE | ID: mdl-31863867

Asunto(s)

Antiinflamatorios/uso terapéutico; Berberina/análogos & derivados; Berberina/uso terapéutico; Colitis/tratamiento farmacológico; Microbioma Gastrointestinal/fisiología; Animales; Antiinflamatorios/farmacología; Berberina/farmacología; Biotransformación; Ciego/microbiología; Colitis/inducido químicamente; Colitis/metabolismo; Colitis/patología; Colon/efectos de los fármacos; Colon/metabolismo; Colon/patología; Sulfato de Dextran; Masculino; Ratones Endogámicos BALB C; Factor 88 de Diferenciación Mieloide/metabolismo; FN-kappa B/metabolismo; Transducción de Señal/efectos de los fármacos; Receptor Toll-Like 4/metabolismo

Palabras clave

Gut microflora; Intestinal epithelial barrier; Metabolite; Oxyberberine; TLR4-MyD88-NF-κB; Ulcerative colitis

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Berberina / Colitis / Microbioma Gastrointestinal / Antiinflamatorios Límite: Animals Idioma: En Revista: Pharmacol Res Asunto de la revista: FARMACOLOGIA Año: 2020 Tipo del documento: Article

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