TLR4 induced Wnt3a-Dvl3 restrains the intensity of inflammation and protects against endotoxin-driven organ failure through GSK3ß/ß-catenin signaling.

Yang, Dongqiang; Li, ShuJian; Duan, Xiaoxian; Ren, Junling; Liang, Shuang; Yakoumatos, Lan; Kang, Yi; Uriarte, Silvia M; Shang, Jia; Li, Wei; Wang, Huizhi

Yang, Dongqiang; Li, ShuJian; Duan, Xiaoxian; Ren, Junling; Liang, Shuang; Yakoumatos, Lan; Kang, Yi; Uriarte, Silvia M; Shang, Jia; Li, Wei; Wang, Huizhi.

Afiliación

Yang D; Department of Infectious Diseases, Henan Provincial People's Hospital (People's Hospital of Zhengzhou University), Zhengzhou 450003, China.
Li S; Department of Neurology, Henan Provincial People's Hospital (People's Hospital of Zhengzhou University), Zhengzhou 450003, China.
Duan X; Department of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, KY 40202, USA.
Ren J; VCU Philips Institute for Oral Health Research, Virginia Commonwealth University School of Dentistry, Department of Oral and Craniofacial Molecular Biology, Richmond, VA, USA.
Liang S; Department of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, KY 40202, USA.
Yakoumatos L; Department of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, KY 40202, USA.
Kang Y; Department of Infectious Diseases, Henan Provincial People's Hospital (People's Hospital of Zhengzhou University), Zhengzhou 450003, China.
Uriarte SM; Department of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, KY 40202, USA.
Shang J; Department of Infectious Diseases, Henan Provincial People's Hospital (People's Hospital of Zhengzhou University), Zhengzhou 450003, China.
Li W; Department of Neurology, Henan Provincial People's Hospital (People's Hospital of Zhengzhou University), Zhengzhou 450003, China.
Wang H; VCU Philips Institute for Oral Health Research, Virginia Commonwealth University School of Dentistry, Department of Oral and Craniofacial Molecular Biology, Richmond, VA, USA. Electronic address: wangh3@vcu.edu.

Mol Immunol ; 118: 153-164, 2020 02.

Article en En | MEDLINE | ID: mdl-31884387

Asunto(s)

Proteínas Dishevelled/metabolismo; Glucógeno Sintasa Quinasa 3 beta/metabolismo; Inflamación/metabolismo; Transducción de Señal/fisiología; Receptor Toll-Like 4/metabolismo; Proteína Wnt3A/metabolismo; beta Catenina/metabolismo; Animales; Citocinas/metabolismo; Endotoxinas/metabolismo; Humanos; Lipopolisacáridos/farmacología; Ratones; Ratones Endogámicos C57BL; Monocitos/metabolismo; Insuficiencia Multiorgánica/metabolismo; Fosforilación/fisiología; Factor de Transcripción ReIA/metabolismo; Factor de Necrosis Tumoral alfa/metabolismo

Palabras clave

Dvl3; Inflammation regulation; TLR4; Wnt3; ß-catenin

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Transducción de Señal / Beta Catenina / Receptor Toll-Like 4 / Proteína Wnt3A / Glucógeno Sintasa Quinasa 3 beta / Proteínas Dishevelled / Inflamación Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Mol Immunol Año: 2020 Tipo del documento: Article País de afiliación: China

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