Oncogenic K-Ras4B Dimerization Enhances Downstream Mitogen-activated Protein Kinase Signaling.

Muratcioglu, Serena; Aydin, Cihan; Odabasi, Ezgi; Ozdemir, E Sila; Firat-Karalar, Elif Nur; Jang, Hyunbum; Tsai, Chung-Jung; Nussinov, Ruth; Kavakli, Ibrahim Halil; Gursoy, Attila; Keskin, Ozlem

Muratcioglu, Serena; Aydin, Cihan; Odabasi, Ezgi; Ozdemir, E Sila; Firat-Karalar, Elif Nur; Jang, Hyunbum; Tsai, Chung-Jung; Nussinov, Ruth; Kavakli, Ibrahim Halil; Gursoy, Attila; Keskin, Ozlem.

Afiliación

Muratcioglu S; Departments of Chemical and Biological Engineering, Research Center for Translational Medicine, Koc University, Istanbul 34450, Turkey.
Aydin C; Departments of Chemical and Biological Engineering, Research Center for Translational Medicine, Koc University, Istanbul 34450, Turkey.
Odabasi E; Departments of Molecular Biology and Genetics, Koc University, Istanbul 34450, Turkey.
Ozdemir ES; Departments of Chemical and Biological Engineering, Research Center for Translational Medicine, Koc University, Istanbul 34450, Turkey.
Firat-Karalar EN; Departments of Molecular Biology and Genetics, Koc University, Istanbul 34450, Turkey.
Jang H; Computational Structural Biology Section, Frederick National Laboratory for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA.
Tsai CJ; Computational Structural Biology Section, Frederick National Laboratory for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA.
Nussinov R; Computational Structural Biology Section, Frederick National Laboratory for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA; Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
Kavakli IH; Departments of Chemical and Biological Engineering, Research Center for Translational Medicine, Koc University, Istanbul 34450, Turkey; Departments of Molecular Biology and Genetics, Koc University, Istanbul 34450, Turkey.
Gursoy A; Departments of Computer Engineering, Research Center for Translational Medicine, Koc University, Istanbul 34450, Turkey. Electronic address: agursoy@ku.edu.tr.
Keskin O; Departments of Chemical and Biological Engineering, Research Center for Translational Medicine, Koc University, Istanbul 34450, Turkey. Electronic address: okeskin@ku.edu.tr.

J Mol Biol ; 432(4): 1199-1215, 2020 02 14.

Article en En | MEDLINE | ID: mdl-31931009

Asunto(s)

Proteínas Quinasas Activadas por Mitógenos/química; Proteínas Quinasas Activadas por Mitógenos/metabolismo; Proteínas Proto-Oncogénicas c-akt/metabolismo; Proteínas Proto-Oncogénicas p21(ras)/química; Proteínas Proto-Oncogénicas p21(ras)/metabolismo; Secuencia de Aminoácidos; Transferencia Resonante de Energía de Fluorescencia; Células HEK293; Humanos; Proteínas Quinasas Activadas por Mitógenos/genética; Simulación de Dinámica Molecular; Mutación/genética; Fosfatidilinositol 3-Quinasas/química; Fosfatidilinositol 3-Quinasas/genética; Fosfatidilinositol 3-Quinasas/metabolismo; Fosforilación; Unión Proteica; Multimerización de Proteína; Estructura Secundaria de Proteína; Proteínas Proto-Oncogénicas c-akt/química; Proteínas Proto-Oncogénicas c-akt/genética; Proteínas Proto-Oncogénicas p21(ras)/genética; Transducción de Señal/genética; Transducción de Señal/fisiología; Proteínas ras/química; Proteínas ras/genética; Proteínas ras/metabolismo

Palabras clave

K-Ras4B dimerization; K-Ras4B mutation; MAPK signaling; interface mutants; membrane localization

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Proto-Oncogénicas p21(ras) / Proteínas Quinasas Activadas por Mitógenos / Proteínas Proto-Oncogénicas c-akt Límite: Humans Idioma: En Revista: J Mol Biol Año: 2020 Tipo del documento: Article País de afiliación: Turquía

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