Urinary ethyl glucuronide (uEtG) as a marker for alcohol consumption in liver transplant candidates: a real-world cohort.
Z Gastroenterol
; 58(1): 30-38, 2020 Jan.
Article
en En
| MEDLINE
| ID: mdl-31931538
ABSTRACT
BACKGROUND:
In order to reduce alcohol relapse after liver transplantation (LT), the German national guidelines for waiting-list maintenance and organ allocation demand a minimum 6-month period of alcohol abstinence pre-LT, confirmed by measuring urinary ethyl glucuronide (uEtG).METHODS:
Between January 2015 and June 2016, uEtG was measured at least once in 339 cirrhotic patients with an indication for LT at the University Medical Center Mainz. uEtG was measured with an enzyme-linked immunosorbent assay (ELISA) screening test (cutoff value 500âµg/L). For uEtG values ≥â500âµg/L, liquid chromatography-mass spectrometry (LC-MS/MS) was performed as a confirmatory assay. Data were collected prospectively in a transplant database.RESULTS:
Of the 339 potential liver transplant candidates, uEtG was negative in 86.4â%. Most patients were male (64.3â%), with an average age of 56.42â±â10.1 years. In the multivariate analysis, mean corpuscular volume (pâ=â0.001), urinary creatinine (pâ=â0.001), gamma-glutamyl transferase (pâ=â0.001), and hemoglobin (pâ=â0.003) were significantly associated with a positive uEtG test result. The sensitivity of the ELISA screening test was 100â% for uEtG values >â2000âµg/L, as confirmed by LC-MS/MS.CONCLUSION:
uEtG is an effective parameter to reveal alcohol consumption by patients on the waiting list for LT. The sensitivity of the ELISA is excellent for uEtG values >â2000âµg/L, for which LC-MS/MS confirmation could be omitted.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Consumo de Bebidas Alcohólicas
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Tamizaje Masivo
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Trasplante de Hígado
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Glucuronatos
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Cirrosis Hepática Alcohólica
Tipo de estudio:
Diagnostic_studies
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Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
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Screening_studies
Límite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Z Gastroenterol
Año:
2020
Tipo del documento:
Article