Direct-acting oral anticoagulants and alopecia: The valuable support of postmarketing data.
Br J Clin Pharmacol
; 86(8): 1654-1660, 2020 08.
Article
en En
| MEDLINE
| ID: mdl-31950530
ABSTRACT
Little is known about the administration of direct-acting oral anticoagulants (DOACs) and the occurrence of alopecia. Our aim was to analyse the reports of alopecia following DOAC administration received until 2 May 2018 from VigiBase, the World Health Organization database. A descriptive analysis of age, sex, seriousness and dechallenge/rechallenge outcome was carried out. For each report, the time-to-onset was evaluated and the causality was assessed by using Naranjo algorithm. Overall, 1316 reports were retrieved, most concerning rivaroxaban (58.8%); 80% of the reports were related to females, in particular to those aged ≥65 years (23.1%). The median value of the time-to-onset was 28 days, with an interquartile range of 63 days. In 54.3% of the reports the causality was assessed as possible. In conclusion, a possible association could exist between DOACs administration and alopecia, but further observational studies are needed to confirm these findings.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Alopecia
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Inhibidores del Factor Xa
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Anticoagulantes
Tipo de estudio:
Observational_studies
Límite:
Adolescent
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Adult
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Aged
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Child
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Female
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Humans
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Male
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Newborn
Idioma:
En
Revista:
Br J Clin Pharmacol
Año:
2020
Tipo del documento:
Article
País de afiliación:
Italia