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CPF impedes cell cycle re-entry of quiescent lung cancer cells through transcriptional suppression of FACT and c-MYC.
Bi, Ling; Xie, Chanlu; Jiao, Lijing; Jin, Shenyi; Hnit, Su Su Thae; Mu, Yao; Wang, Yilun; Wang, Qian; Ge, Guangbo; Wang, Yaqiao; Zhao, Xiaodong; Shi, Xinglong; Kang, Yani; De Souza, Paul; Liu, Tao; Zhou, Jia; Xu, Ling; Dong, Qihan.
Afiliación
  • Bi L; Department of Oncology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Xie C; School of Science and Health, National Institute of Complementary Medicine, Western Sydney University, Penrith South, NSW, Australia.
  • Jiao L; Chinese Medicine Anti-cancer Evaluation Program, Greg Brown Laboratory, Central Clinical School and Charles Perkins Center, The University of Sydney, Sydney, NSW, Australia.
  • Jin S; Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
  • Hnit SST; Department of Oncology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Mu Y; Department of Oncology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Wang Y; School of Science and Health, National Institute of Complementary Medicine, Western Sydney University, Penrith South, NSW, Australia.
  • Wang Q; Chinese Medicine Anti-cancer Evaluation Program, Greg Brown Laboratory, Central Clinical School and Charles Perkins Center, The University of Sydney, Sydney, NSW, Australia.
  • Ge G; Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
  • Wang Y; Chinese Medicine Anti-cancer Evaluation Program, Greg Brown Laboratory, Central Clinical School and Charles Perkins Center, The University of Sydney, Sydney, NSW, Australia.
  • Zhao X; Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
  • Shi X; Chinese Medicine Anti-cancer Evaluation Program, Greg Brown Laboratory, Central Clinical School and Charles Perkins Center, The University of Sydney, Sydney, NSW, Australia.
  • Kang Y; Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
  • De Souza P; Origins of Cancer Program, Centenary Institute, Camperdown, NSW, Australia.
  • Liu T; Sydney Medical School, the University of Sydney, Sydney, NSW, Australia.
  • Zhou J; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Xu L; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Dong Q; Shanghai Center for Systems Biology, Shanghai Jiao Tong University, Shanghai, China.
J Cell Mol Med ; 24(3): 2229-2239, 2020 02.
Article en En | MEDLINE | ID: mdl-31960591
ABSTRACT
Blockade of cell cycle re-entry in quiescent cancer cells is a strategy to prevent cancer progression and recurrence. We investigated the action and mode of action of CPF mixture (Coptis chinensis, Pinellia ternata and Fructus trichosanthis) in impeding a proliferative switch in quiescent lung cancer cells. The results indicated that CPF impeded cell cycle re-entry in quiescent lung cancer cells by reduction of FACT and c-MYC mRNA and protein levels, with concomitant decrease in H3K4 tri-methylation and RNA polymerase II occupancy at FACT and c-MYC promoter regions. Animals implanted with quiescent cancer cells that had been exposed to CPF had reduced tumour volume/weight. Thus, CPF suppresses proliferative switching through transcriptional suppression of FACT and the c-MYC, providing a new insight into therapeutic target and intervention method in impeding cancer recurrence.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Transcripción Genética / Extractos Vegetales / Proteínas del Grupo de Alta Movilidad / Proteínas Proto-Oncogénicas c-myc / Factores de Elongación Transcripcional / Proteínas de Unión al ADN / Neoplasias Pulmonares Límite: Animals / Humans / Male Idioma: En Revista: J Cell Mol Med Asunto de la revista: BIOLOGIA MOLECULAR Año: 2020 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Transcripción Genética / Extractos Vegetales / Proteínas del Grupo de Alta Movilidad / Proteínas Proto-Oncogénicas c-myc / Factores de Elongación Transcripcional / Proteínas de Unión al ADN / Neoplasias Pulmonares Límite: Animals / Humans / Male Idioma: En Revista: J Cell Mol Med Asunto de la revista: BIOLOGIA MOLECULAR Año: 2020 Tipo del documento: Article País de afiliación: China