Competitive role between fibrinogen and albumin on thixotropy of red cell suspensions.
Biorheology
; 25(1-2): 349-54, 1988.
Article
en En
| MEDLINE
| ID: mdl-3196832
ABSTRACT
Plasmatic proteins, namely fibrinogen and globulins, play a major role in red blood cell (RBC) aggregation which is accountable for the three-dimensional structure of blood. Consequently, blood rheological properties linked to this structure must be modified when the protein plasma content changes. This paper gives results and related comments on thixotropic properties of RBC suspensions (0.45 hematocrit) in isotonic solutions containing various amount of fibrinogen to which albumin is added. Thixotropic behavior of these RBC suspensions is studied with a low inertia coaxial cylinders viscometer at a shear rate step of Y = 1 s-1. Rheograms are interpreted in term of thixotropy coefficient. The main conclusion is that albumin improves RBC disaggregability of whole blood, resulting probably from a competitive effect between fibrinogen and albumin in the RBC aggregation process.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fibrinógeno
/
Albúmina Sérica
/
Agregación Eritrocitaria
Límite:
Humans
Idioma:
En
Revista:
Biorheology
Año:
1988
Tipo del documento:
Article
País de afiliación:
Francia