Movement of the X chromosome in epilepsy.
Science
; 242(4886): 1687-91, 1988 Dec 23.
Article
en En
| MEDLINE
| ID: mdl-3201257
ABSTRACT
The position of selected chromosomes was assessed in samples of normal and epileptic human cortex with biotinylated probes specific for individual chromosome domains. Optical sectioning provided a rapid method for three-dimensional resolution of in situ hybridization signals in interphase cells, and solid models were reconstructed from digitized images for detailed rotational studies. There was a dramatic repositioning of the X chromosome in neurons of both males and females in electrophysiologically defined seizure foci. Other chromosomes (1, 9, and Y) showed more subtle positional changes. Specifically altered nuclear patterns involving the X chromosome may become established and create the genetic memory for intractable seizure activity.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Cromosoma X
/
Epilepsia
Límite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Science
Año:
1988
Tipo del documento:
Article