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Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRASG12C.
Kettle, Jason G; Bagal, Sharan K; Bickerton, Sue; Bodnarchuk, Michael S; Breed, Jason; Carbajo, Rodrigo J; Cassar, Doyle J; Chakraborty, Atanu; Cosulich, Sabina; Cumming, Iain; Davies, Michael; Eatherton, Andrew; Evans, Laura; Feron, Lyman; Fillery, Shaun; Gleave, Emma S; Goldberg, Frederick W; Harlfinger, Stephanie; Hanson, Lyndsey; Howard, Martin; Howells, Rachel; Jackson, Anne; Kemmitt, Paul; Kingston, Jennifer K; Lamont, Scott; Lewis, Hilary J; Li, Songlei; Liu, Libin; Ogg, Derek; Phillips, Christopher; Polanski, Radek; Robb, Graeme; Robinson, David; Ross, Sarah; Smith, James M; Tonge, Michael; Whiteley, Rebecca; Yang, Junsheng; Zhang, Longfei; Zhao, Xiliang.
Afiliación
  • Kettle JG; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.
  • Bagal SK; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.
  • Bickerton S; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.
  • Bodnarchuk MS; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.
  • Breed J; Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, U.K.
  • Carbajo RJ; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.
  • Cassar DJ; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.
  • Chakraborty A; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.
  • Cosulich S; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.
  • Cumming I; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.
  • Davies M; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.
  • Eatherton A; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.
  • Evans L; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.
  • Feron L; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.
  • Fillery S; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.
  • Gleave ES; Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, U.K.
  • Goldberg FW; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.
  • Harlfinger S; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.
  • Hanson L; Oncology R&D, AstraZeneca, Alderley Park SK10 4TG, U.K.
  • Howard M; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.
  • Howells R; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.
  • Jackson A; Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, U.K.
  • Kemmitt P; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.
  • Kingston JK; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.
  • Lamont S; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.
  • Lewis HJ; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.
  • Li S; Pharmaron Beijing Co., Ltd. 6 Taihe Road BDA, Beijing 100176 P. R. China.
  • Liu L; Pharmaron Beijing Co., Ltd. 6 Taihe Road BDA, Beijing 100176 P. R. China.
  • Ogg D; Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, U.K.
  • Phillips C; Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, U.K.
  • Polanski R; Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, U.K.
  • Robb G; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.
  • Robinson D; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.
  • Ross S; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.
  • Smith JM; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.
  • Tonge M; Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, U.K.
  • Whiteley R; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.
  • Yang J; Pharmaron Beijing Co., Ltd. 6 Taihe Road BDA, Beijing 100176 P. R. China.
  • Zhang L; Pharmaron Beijing Co., Ltd. 6 Taihe Road BDA, Beijing 100176 P. R. China.
  • Zhao X; Pharmaron Beijing Co., Ltd. 6 Taihe Road BDA, Beijing 100176 P. R. China.
J Med Chem ; 63(9): 4468-4483, 2020 05 14.
Article en En | MEDLINE | ID: mdl-32023060
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Piperazinas / Quinazolinas / Proteínas Proto-Oncogénicas p21(ras) / Quinolonas / Neoplasias / Antineoplásicos Límite: Animals / Humans / Male Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Piperazinas / Quinazolinas / Proteínas Proto-Oncogénicas p21(ras) / Quinolonas / Neoplasias / Antineoplásicos Límite: Animals / Humans / Male Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido