Two-year outcome data suggest that less invasive surfactant administration (LISA) is safe. Results from the follow-up of the randomized controlled AMV (avoid mechanical ventilation) study.
Eur J Pediatr
; 179(8): 1309-1313, 2020 Aug.
Article
en En
| MEDLINE
| ID: mdl-32067100
ABSTRACT
Less invasive surfactant administration (LISA) is a method to deliver surfactant to spontaneously breathing premature infants via a thin catheter. Here we report the two-year outcome from the AMV (avoid mechanical ventilation) study, the first randomized controlled trial on this mode of surfactant delivery. No statistically significant differences in weight, length or neurodevelopmental outcome (Bayley II scores) were found between the LISA intervention group (n = 95) and the control group (n = 84) that received standard treatment.Conclusion:
No differences in outcome were observed at 2 years. LISA seems safe in that aspect. What is Known ⢠LISA is a method that is in increasing use for surfactant delivery to spontaneously breathing infants. LISA reduces the need for mechanical ventilation. What is New ⢠Outcome data at 2 years from the first randomized study with LISA raise no safety concerns in comparison to a group of infants that received standard treatment.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Síndrome de Dificultad Respiratoria del Recién Nacido
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Surfactantes Pulmonares
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Trastornos del Neurodesarrollo
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Trastornos del Crecimiento
Tipo de estudio:
Clinical_trials
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Diagnostic_studies
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Etiology_studies
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Observational_studies
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Prognostic_studies
Límite:
Child, preschool
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Female
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Humans
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Male
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Newborn
Idioma:
En
Revista:
Eur J Pediatr
Año:
2020
Tipo del documento:
Article
País de afiliación:
Alemania