Delayed Akt suppression in the lipopolysaccharide-induced acute lung injury promotes resolution that is associated with enhanced effector regulatory T cells.

Artham, Sandeep; Verma, Arti; Alwhaibi, Abdulrahman; Adil, Mir S; Manicassamy, Santhakumar; Munn, David H; Somanath, Payaningal R

Artham, Sandeep; Verma, Arti; Alwhaibi, Abdulrahman; Adil, Mir S; Manicassamy, Santhakumar; Munn, David H; Somanath, Payaningal R.

Afiliación

Artham S; Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia and Charlie Norwood Veterans Affairs Medical Center, Augusta, Georgia.
Verma A; Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia and Charlie Norwood Veterans Affairs Medical Center, Augusta, Georgia.
Alwhaibi A; Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia and Charlie Norwood Veterans Affairs Medical Center, Augusta, Georgia.
Adil MS; Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia and Charlie Norwood Veterans Affairs Medical Center, Augusta, Georgia.
Manicassamy S; Department of Biochemistry and Molecular Biology, Augusta University, Augusta, Georgia.
Munn DH; Georgia Cancer Center, Augusta University, Augusta, Georgia.
Somanath PR; Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia and Charlie Norwood Veterans Affairs Medical Center, Augusta, Georgia.

Am J Physiol Lung Cell Mol Physiol ; 318(4): L750-L761, 2020 04 01.

Article en En | MEDLINE | ID: mdl-32073894

Asunto(s)

Lesión Pulmonar Aguda/metabolismo; Proteínas Proto-Oncogénicas c-akt/metabolismo; Linfocitos T Reguladores/metabolismo; Lesión Pulmonar Aguda/inducido químicamente; Traslado Adoptivo/métodos; Animales; Antígenos CD/metabolismo; Antígenos CD4/metabolismo; Modelos Animales de Enfermedad; Femenino; Factores de Transcripción Forkhead/metabolismo; Cadenas alfa de Integrinas/metabolismo; Lipopolisacáridos/farmacología; Pulmón/efectos de los fármacos; Pulmón/metabolismo; Masculino; Ratones; Ratones Endogámicos C57BL; Ratones Noqueados; Neutrófilos/efectos de los fármacos; Neutrófilos/metabolismo; Edema Pulmonar/inducido químicamente; Edema Pulmonar/metabolismo; Bazo; Linfocitos T Reguladores/efectos de los fármacos

Palabras clave

Akt; PTEN; acute lung injury; regulatory T cells; triciribine

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Linfocitos T Reguladores / Proteínas Proto-Oncogénicas c-akt / Lesión Pulmonar Aguda Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Am J Physiol Lung Cell Mol Physiol Asunto de la revista: BIOLOGIA MOLECULAR / FISIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Georgia

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google