Targeting proinsulin to local immune cells using an intradermal microneedle delivery system; a potential antigen-specific immunotherapy for type 1 diabetes.

Arikat, Farah; Hanna, Stephanie J; Singh, Ravinder K; Vilela, Luciano; Wong, F Susan; Dayan, Colin M; Coulman, Sion A; Birchall, James C

Arikat, Farah; Hanna, Stephanie J; Singh, Ravinder K; Vilela, Luciano; Wong, F Susan; Dayan, Colin M; Coulman, Sion A; Birchall, James C.

Afiliación

Arikat F; School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff CF10 3NB, UK.
Hanna SJ; School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Singh RK; School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Vilela L; Biomm S.A., Nova Lima, MG 34019-000, Brazil.
Wong FS; School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Dayan CM; School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Coulman SA; School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff CF10 3NB, UK. Electronic address: CoulmanSA@cardiff.ac.uk.
Birchall JC; School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff CF10 3NB, UK.

J Control Release ; 322: 593-601, 2020 06 10.

Article en En | MEDLINE | ID: mdl-32087298

Asunto(s)

Diabetes Mellitus Tipo 1; Proinsulina; Animales; Linfocitos T CD8-positivos; Diabetes Mellitus Tipo 1/terapia; Humanos; Inmunoterapia; Ratones; Ratones Endogámicos NOD

Palabras clave

Diabetes; Immunotherapy; Microneedle; Proinsulin; Skin; Tolerance

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proinsulina / Diabetes Mellitus Tipo 1 Límite: Animals / Humans Idioma: En Revista: J Control Release Asunto de la revista: FARMACOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido

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