Benzoxazole Derivative K313 Induces Cell Cycle Arrest, Apoptosis and Autophagy Blockage and Suppresses mTOR/p70S6K Pathway in Nalm-6 and Daudi Cells.

Zhong, Wenying; Tang, Xinwen; Liu, Yang; Zhou, Chunyu; Liu, Pan; Li, Enhui; Zhong, Peilin; Lv, Haoxue; Zou, Qiang; Wang, Maolin

Zhong, Wenying; Tang, Xinwen; Liu, Yang; Zhou, Chunyu; Liu, Pan; Li, Enhui; Zhong, Peilin; Lv, Haoxue; Zou, Qiang; Wang, Maolin.

Afiliación

Zhong W; Key Laboratory of Bio-resources and Eco-environment of the Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610065, China.
Tang X; Center of Science and Research, Chengdu Medical College, Chengdu 610513, China.
Liu Y; Center of Science and Research, Chengdu Medical College, Chengdu 610513, China.
Zhou C; School of Pharmacy, Chengdu Medical College, Chengdu 610083, China.
Liu P; College of Biological Science and Technology, Chengdu Medical College, Chengdu 610500, China.
Li E; School of Pharmacy, Chengdu Medical College, Chengdu 610083, China.
Zhong P; School of Pharmacy, Chengdu Medical College, Chengdu 610083, China.
Lv H; School of Pharmacy, Chengdu Medical College, Chengdu 610083, China.
Zou Q; Center of Science and Research, Chengdu Medical College, Chengdu 610513, China.
Wang M; Key Laboratory of Bio-resources and Eco-environment of the Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610065, China.

Molecules ; 25(4)2020 Feb 21.

Article en En | MEDLINE | ID: mdl-32098126

Asunto(s)

Benzoxazoles/farmacología; Linfoma/tratamiento farmacológico; Proteínas Quinasas S6 Ribosómicas 70-kDa/genética; Serina-Treonina Quinasas TOR/genética; Animales; Antineoplásicos Fitogénicos/farmacología; Apoptosis/efectos de los fármacos; Autofagia/efectos de los fármacos; Benzoxazoles/química; Puntos de Control del Ciclo Celular/efectos de los fármacos; Línea Celular Tumoral; Proliferación Celular/efectos de los fármacos; Supervivencia Celular/efectos de los fármacos; Humanos; Leucocitos Mononucleares; Linfoma/genética; Linfoma/patología; Ratones; Células RAW 264.7; Transducción de Señal/efectos de los fármacos

Palabras clave

B-cell Burkitt's lymphoma; B-cell acute lymphoblastic leukemia; K313; apoptosis; autophagy blockage; cell cycle arrest; mitochondrial pathway

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Benzoxazoles / Proteínas Quinasas S6 Ribosómicas 70-kDa / Serina-Treonina Quinasas TOR / Linfoma Límite: Animals / Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: China

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