Analysis of Single Circulating Tumor Cells in Renal Cell Carcinoma Reveals Phenotypic Heterogeneity and Genomic Alterations Related to Progression.

Cappelletti, Vera; Verzoni, Elena; Ratta, Raffaele; Vismara, Marta; Silvestri, Marco; Montone, Rosanna; Miodini, Patrizia; Reduzzi, Carolina; Claps, Melanie; Sepe, Pierangela; Daidone, Maria Grazia; Procopio, Giuseppe

Cappelletti, Vera; Verzoni, Elena; Ratta, Raffaele; Vismara, Marta; Silvestri, Marco; Montone, Rosanna; Miodini, Patrizia; Reduzzi, Carolina; Claps, Melanie; Sepe, Pierangela; Daidone, Maria Grazia; Procopio, Giuseppe.

Afiliación

Cappelletti V; Biomarker Unit, Department of Applied Research and Technological Development, Fondazione IRCCS Istituto Nazionale Tumori di Milano, 20133 Milano, Italy.
Verzoni E; Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Tumori, 20133 Milano, Italy.
Ratta R; Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Tumori, 20133 Milano, Italy.
Vismara M; Biomarker Unit, Department of Applied Research and Technological Development, Fondazione IRCCS Istituto Nazionale Tumori di Milano, 20133 Milano, Italy.
Silvestri M; Biomarker Unit, Department of Applied Research and Technological Development, Fondazione IRCCS Istituto Nazionale Tumori di Milano, 20133 Milano, Italy.
Montone R; Clinical Trial Center, Fondazione IRCCS Istituto Nazionale Tumori, 20133 Milano, Italy.
Miodini P; Biomarker Unit, Department of Applied Research and Technological Development, Fondazione IRCCS Istituto Nazionale Tumori di Milano, 20133 Milano, Italy.
Reduzzi C; Biomarker Unit, Department of Applied Research and Technological Development, Fondazione IRCCS Istituto Nazionale Tumori di Milano, 20133 Milano, Italy.
Claps M; Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Tumori, 20133 Milano, Italy.
Sepe P; Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Tumori, 20133 Milano, Italy.
Daidone MG; Biomarker Unit, Department of Applied Research and Technological Development, Fondazione IRCCS Istituto Nazionale Tumori di Milano, 20133 Milano, Italy.
Procopio G; Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Tumori, 20133 Milano, Italy.

Int J Mol Sci ; 21(4)2020 Feb 21.

Article en En | MEDLINE | ID: mdl-32098246

Asunto(s)

Biomarcadores de Tumor; Carcinoma de Células Renales; Deleción Cromosómica; Cromosomas Humanos Par 9/genética; Neoplasias Renales; Células Neoplásicas Circulantes; Análisis de la Célula Individual; Biomarcadores de Tumor/genética; Biomarcadores de Tumor/metabolismo; Carcinoma de Células Renales/genética; Carcinoma de Células Renales/metabolismo; Carcinoma de Células Renales/patología; Femenino; Secuenciación de Nucleótidos de Alto Rendimiento; Humanos; Neoplasias Renales/genética; Neoplasias Renales/metabolismo; Neoplasias Renales/patología; Masculino; Persona de Mediana Edad; Células Neoplásicas Circulantes/metabolismo; Células Neoplásicas Circulantes/patología

Palabras clave

cancer evolution; circulating tumor cells; copy number alterations; heterogeneity; renal cell cancer; single-cell analysis

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Cromosomas Humanos Par 9 / Carcinoma de Células Renales / Biomarcadores de Tumor / Deleción Cromosómica / Análisis de la Célula Individual / Neoplasias Renales / Células Neoplásicas Circulantes Tipo de estudio: Clinical_trials Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Int J Mol Sci Año: 2020 Tipo del documento: Article País de afiliación: Italia

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