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Transglutaminase 3 Reduces the Severity of Psoriasis in Imiquimod-Treated Mouse Skin.
Piro, Maria Cristina; Ventura, Alessandra; Smirnov, Artem; Saggini, Andrea; Lena, Anna Maria; Mauriello, Alessandro; Bianchi, Luca; Melino, Gerry; Candi, Eleonora.
Afiliación
  • Piro MC; Department of Experimental Medicine, TOR, University of Rome "Tor Vergata", 00133 Rome, Italy.
  • Ventura A; Dermatology Unit, Department of Biotechnological and Applied Clinical Science, University of L'Aquila, IT-67100 L'Aquila, Italy.
  • Smirnov A; Department of Experimental Medicine, TOR, University of Rome "Tor Vergata", 00133 Rome, Italy.
  • Saggini A; Department of Experimental Medicine, TOR, University of Rome "Tor Vergata", 00133 Rome, Italy.
  • Lena AM; Department of Experimental Medicine, TOR, University of Rome "Tor Vergata", 00133 Rome, Italy.
  • Mauriello A; Department of Experimental Medicine, TOR, University of Rome "Tor Vergata", 00133 Rome, Italy.
  • Bianchi L; Dermatology Unit, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.
  • Melino G; Department of Experimental Medicine, TOR, University of Rome "Tor Vergata", 00133 Rome, Italy.
  • Candi E; Medical Research Council, University of Cambridge, Cambridge CB21QP, UK.
Int J Mol Sci ; 21(5)2020 Feb 25.
Article en En | MEDLINE | ID: mdl-32106600
ABSTRACT
Four transglutaminase (TG) isoforms have been detected in epidermal keratinocytes TG1, TG2, TG3, and TG5. Except for TG1 and TG3, their contribution to keratinocyte development and structure remains undefined. In this paper, we focused on the roles of TG2 and TG3 in imiquimod-induced psoriasis in mouse skin. We evaluated the severity of psoriasis markers in the skin of imiquimod-treated TG3 null and TG2 null mice. Our results showed that compromised TG3KO mouse skin was more responsive than WT or TG2KO mouse skin to the action of the pro-inflammatory drug imiquimod.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Psoriasis / Transglutaminasas / Proteínas de Unión al GTP Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2020 Tipo del documento: Article País de afiliación: Italia
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Psoriasis / Transglutaminasas / Proteínas de Unión al GTP Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2020 Tipo del documento: Article País de afiliación: Italia